B lymphocyte


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B lym·pho·cyte

an immunologically important lymphocyte that is not thymus dependent, is short-lived, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins; that is, it is the precursor of the plasma cell and expresses surface immunoglobulins (SIGS) but does not release them. It does not play a direct role in cell-mediated immunity. B lymphocyte can be characterized immunophenotypically by CD19 surface markers.
See also: T lymphocyte.
Synonym(s): B cell (2)

B lymphocyte

also

B-lymphocyte

(bē′lĭm′fə-sīt′)
n.
See B cell.

B cell

One of the two major classes of lymphocytes, which comprises 30% of circulating lymphocytes and is concentrated in the follicular zones of lymphoid tissue (in contrast T cells, which are located in the deep cortex). B cells are responsible for antibody production, a transformation evoked by interaction with the appropriate CD4 T-helper cells. Igs are responsible for specific defence against viruses and bacteria, immune surveillance (cytolysis of potentially malignant “self” cells, mediation of antibody-dependent cell cytotoxicity), allergic reactions, formation of antigen-antibody complexes and production of cytokines; surface and cytoplasmic antigens indicate the degree of B-cell maturation and function. Cytoplasmic IgM is present in pre-B cells and surface Ig in mature B lymphoctytes and plasma cells; complement receptors are seen in mature cells. B cell markers include CD9, CD10, CD19, CD20, CD24, Fc receptor, B1, BA-1 and B4 Ia.

B lym·pho·cyte

(lim'fŏ-sīt)
A lymphocyte that resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins, i.e., it is the precursor of the plasma cell and expresses immunoglobulins on its surface but does not release them. It does not play a direct role in cell-mediated immunity.
See also: T lymphocyte

B lymphocyte

A type of lymphocyte that circulates in the blood and lymph and produces antibodies when it encounters specific antigens. B lymphocytes are also called B cells.
Mentioned in: Lymphocytopenia

B lym·pho·cyte

(lim'fŏ-sīt)
Immunologically important lymphocyte that is not thymus dependent, is short lived, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins.
References in periodicals archive ?
For example, Navarro and colleagues [67] demonstrated the ability of chronic moderate-intensity exercise (eight weeks of treadmill running) to modulate the activation, proliferation, cytokine production, and glucose and glutamine metabolism of T and B lymphocytes.
For example, increased expression of IL-2 and its receptor (IL-2R) and decreased expression of IL-4 and its receptor (IL-4R) were observed in T cells relative to B lymphocytes. These data suggest that chronic moderate exercise in healthy animals primarily enhances the Th1 response phenotype [67].
In research to be published in the May PEDIATRIC RESEARCH, Goldman finds that certain soluble proteins in breast milk can activate macrophages -- white blood cells that complement B lymphocytes in the immune response.
In contrast, the inflammatory infiltrates in patients with Mediterranean spotted fever were mainly characterized by macrophages (p = 0.04, Figure 4) and T and B lymphocytes. The relative amounts of vessel formation were similar in the 2 diseases.
(5) The immunologic theory is supported by the findings of a predominance of B lymphocytes in a pattern that is similar to that seen in reactive hyperplasia.
While the thymus gland has long been considered the executive director of T-lymphocyte production, B lymphocytes are thought to come from the bone marrow in humans.
The interaction of epithelial cells with T and B lymphocytes induces epithelial cells to differentiate into M cells in vitro (5), indicating the importance of lymphocyte-epithelial cell interactions for maintaining M cells in the follicle-associated epithelium of the Peyers patches (Figure 1).