azoles


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Related to azoles: Allylamines

azoles

fungistatic agents (e.g. miconazole; clotrimazole) used daily for at least 4 weeks to treat tinea pedis (Table 1)
Table 1: Treatment of fungal infections of skin and nails
Infection siteAgent
Antimycotic agent (for the treatment of dermatophytosis)
SkinTopical allylamine (e.g. 1% terbinafine cream for 7 days)
Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days)
Topical 0.25% amorolfine
Topical 1% econazole
Topical griseofulvin spray (400 μg puff daily for 14 days)
Topical 1% sulconazole
Topical tea tree (manuka) oil
Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid)
Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid)
Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder
Systemic terbinafine (250 mg daily for 2 weeks)
Systemic itraconazole (100 mg daily for 15 days)
Systemic griseofulvin (500 mg daily )
NailTopical amorolfine 0.25% lacquer as an adjunct to systemic treatment
Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid)
Topical 28% tioconazole lacquer
Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil)
Other topicals: strong iodine 10% solution
Systemic terbinafine (250 mg daily for 12-16 weeks)
Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times)
Anticandidal agent (for the treatment of candidiasis)
SkinTopical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole)
Topical nystatin (100 000 units ± 1% tolnaftate)
Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
SkinTopical 2% ketoconazole
Topical 2.5% selenium sulphide
Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine)
Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole
References in periodicals archive ?
Of those, 136 (38%) reported clinical failure of therapy for [greater than or equal to]1 patient, despite 290 (80%) physicians having used therapeutic drug monitoring to titrate azole therapy.
22) This is especially pertinent in a case like this one, where a lower statin dose may result in a lower chance of the pharmacist alerting the prescribing physician (16) and when an azole is used that is a comparatively weaker CYP450 inhibitor than other azoles such as itraconazole.
Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.
Regarding the azole antifungal agents, our results demonstrated that prolonged exposure of the clinical isolates to fluconazole showed an increased MIC for itraconazole characterizing cross-resistance among azoles (Table 1).
4 million pregnancies that occurred from 1997 to 2013, oral fluconazole increased the risk of spontaneous abortion from 7 to 22 weeks' gestation, compared with no exposure to fluconazole and with exposure to a topical azole.
The use of azoles for the treatment of VVC over time has resulted in the selection of strains resistant to these compounds [38].
tropicalis were found to be resistant from the present study; hence, it may be inferred that fluconazole is the most efficient of the azoles for treating the local VVC cases other than candidiasis caused by C.
So when I have a moist macerated space, I like an azole.
The Infectious Diseases Society of America made no preference and recommends both local azoles and oral fluconazole (10).
Terbinafine and topical azoles rapidly penetrate the stratum corneum and quickly kill the infection with a high response rate, but their use is not recommended for children.
pachydermatis is most susceptible to topical azoles like Miconazole, Ketoconazole and Clotrimazole (Outerbridge 2006).
For treatment of coccidioidomycosis, as well as fungi and molds (particularly Candida, Cryptococcus, and Aspergillus), there has been some evidence that there is antagonism between lipophilic azoles and amphotericin in vitro; however, this has not been proven in clinical trials.