azole

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Related to Azoles: Allylamines

pyr·role

(pir'ōl),
Divinylenimine; a heterocyclic compound found in many biologically important substances, for example, heme.
Synonym(s): azole, imidole

azole

(ăz′ōl′, ā′zōl′)
n.
Any of a class of organic compounds that have a five-membered heterocyclic ring with at least one nitrogen and two double bonds and that also may contain another heteroatom.

azole

Any of a family of broad-spectrum antifungals, including ketoconazole, fluconazole and itraconazole.
 
Indications
Blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and in sporotrichosis.
 
Adverse effects
Nausea, vomiting, anorexia, rash, pruritus, nonspecific increased liver enzymes, anaemia, leukopenia, thrombocytopenia, headache and others.
 
Drug interactions
Plasma levels of azoles are decreased by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin and rifampin.

azole

Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.

pyr·role

(pir'ōl)
A heterocyclic compound found in many biologically important substances.
Synonym(s): azole, imidole.
References in periodicals archive ?
But as azoles began destroying more prevalent fungi, an opportunity arrived for C.
Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.
Department of Agirgulture's National Agriculture Statistics Service (USDA-NASS) Database (USDA-NASS 2011) to identify commonly used pesticides in the State of Washington' s apple production, including organophosphate (OP), neonicotinoid, or carbamate insecticides; azole, or anilide fungicides; and herbicides like 2,4-dichlorophenoxyacetic acid (2,4-D), and pendimethalin.
Patients with a concomitant systemic illness, immunosuppression, extensive involvement (>20% body surface area) or known hyper-sensitivity to azole antifungals were excluded from the study.
As suggested above, azoles are widely used in the medical industry as therapeutic agents against pathogenic fungi; that is, as antifungal drugs.
Teniendo en cuenta lo anterior, un estudio realizado por Cordeiro y colaboradores (32) evaluo los efectos del farnesol en la susceptibilidad antifungica de especimenes de Candida con resistencia in vitro a anfotericina B, azoles y caspofungina.
Azoles inhibit fungal cytochrome P450-dependent 14[alpha]-demethylation of lanosterol, leading to substitution of methylated sterols in the membrane and depletion of ergosterol, which results in an accumulation of precursors with abnormalities in the fungal membrane.
Echinocandins are fungicidal against all Candida species as compared to azoles which are fungistatic under standard testing conditions [33].
Ketoconazole is an imidazole derivative, meaning that there are 2 nitrogen atoms in the azole ring.
(6,7) The trigger for our patient's statin-induced rhabdomyolysis was fluconazole, a known moderate inhibitor of CYP3A4, which is comparatively weaker than certain potent azoles like itraconazole or ketoconazole.