But as azoles
began destroying more prevalent fungi, an opportunity arrived for C.
Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole
Department of Agirgulture's National Agriculture Statistics Service (USDA-NASS) Database (USDA-NASS 2011) to identify commonly used pesticides in the State of Washington' s apple production, including organophosphate (OP), neonicotinoid, or carbamate insecticides; azole
, or anilide fungicides; and herbicides like 2,4-dichlorophenoxyacetic acid (2,4-D), and pendimethalin.
Patients with a concomitant systemic illness, immunosuppression, extensive involvement (>20% body surface area) or known hyper-sensitivity to azole
antifungals were excluded from the study.
resistance in Aspergillus fumigatus: a growing public health concern.
As suggested above, azoles
are widely used in the medical industry as therapeutic agents against pathogenic fungi; that is, as antifungal drugs.
Teniendo en cuenta lo anterior, un estudio realizado por Cordeiro y colaboradores (32) evaluo los efectos del farnesol en la susceptibilidad antifungica de especimenes de Candida con resistencia in vitro a anfotericina B, azoles
inhibit fungal cytochrome P450-dependent 14[alpha]-demethylation of lanosterol, leading to substitution of methylated sterols in the membrane and depletion of ergosterol, which results in an accumulation of precursors with abnormalities in the fungal membrane.
Echinocandins are fungicidal against all Candida species as compared to azoles
which are fungistatic under standard testing conditions .
Ketoconazole is an imidazole derivative, meaning that there are 2 nitrogen atoms in the azole
(6,7) The trigger for our patient's statin-induced rhabdomyolysis was fluconazole, a known moderate inhibitor of CYP3A4, which is comparatively weaker than certain potent azoles
like itraconazole or ketoconazole.