azelaic acid


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azelaic acid

 [az″ĕ-la´ik]
a dicarboxylic acid occurring in whole grains and animal products; it has antibacterial effects on both aerobic and anaerobic organisms, particularly Propionibacterium acnes and Staphylococcus epidermidis, normalizes keratinization, and has a cytotoxic effect on malignant or hyperactive melanocytes; applied topically in the treatment of acne vulgaris.

azelaic acid

A substance first identified in rancid oleic acid which interferes with anerobic glycolysis and mitochondrial activity. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, possibly by inhibiting microbial protein synthesis.

Dermatology
AZELEX Cream is indicated for the topical treatment of mild to moderate inflammatory acne vulgaris; another formulation, Finacea, is a topical gel used to manage inflammatory papules and pustules of mild to moderate rosacea.

Fringe oncology
Some anecdotal data suggest possible efficacy of alelaic acid in managing lentigo maligna, a form of melanoma.

azelaic acid

An antibacterial drug used externally in the form of a skin cream. A brand name is Skinoren.
References in periodicals archive ?
A second phase III study enrolled 251 rosacea patients, who applied topical 15% azelaic acid gel or metronidazole 0.75% gel to affected areas for 15 weeks, Dr.
A randomized investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs.
The following medications were significantly superior to placebo: topical metronidazole, benzoyl peroxide 5%/ erythromycin 3% gel, benzoyl peroxide 5%/clindamycin 1% gel, benzoyl peroxide alone, azelaic acid, and sodium sulfacetamide 10%/sulfur 5%.
Hyperpigmentation can be treated with hydroquinone and azelaic acid (Finacea), as well as many other preparations.
Tenders are invited for Ph No.:49102 Azelaic Acid 10 Percent W/W
The management of melasma includes the use of broad spectrum sunscreen in combination with depigmenting agents, such as hydroquinone, retinoic acid, azelaic acid, kojic acid, flavonoid extracts, fish oil, green tea, deoxyarbutin and liquiritin.
This acid category includes ferulic acid, azelaic acid, retinoic acid and alpha lipoic acid.
Pharmaceutical company Bayer HealthCare reported on Friday that it has received the US Food & Drug Administration's (FDA) approval for Finacea (azelaic acid) Foam, 15% for topical treatment of the inflammatory papules and pustules of mild to moderate rosacea.
Moreover, in a related single-blind, 9-month safety study involving 910 patients on ivermectin 1% cream once daily and 481 on topical azelaic acid 15% twice daily, the rate of treatment-related dermatologic adverse events was 1.3% in the ivermectin arm, compared with 5.3% with azelaic acid.
Historically the treatment of melasma has been challenging and the various modalities of treatment include broad spectrum sunscreens, hydroquinone in various concentration, tretinoin, fluorinated steroids, kojic acid, salicylic acid, glycolic acid, azelaic acid, lactic acid, chemical peels, laser therapy like Q switched ruby, alexandrite, Nd; YAG laser etc.
BERLIN -- Azelaic acid (AzA), a naturally occurring dicarboxylic acid, has been shown to be effective in the treatment of both acne and rosacea.