senna

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senna

 [sen´ah]
the dried leaflets of Cassia acutiflora; used in a syrup, fluid extract, or compound powder as a cathartic.

senna, sennosides

Argoral (CA), Black Draught, Ex-Lax Gentle, Fleet Pedia-Lax Quick Dissolve, Fletcher's, Maximum Relief Ex-Lax, Nu-Lax (CA), Perdiem, Senexon, Senna-Gen, Sennatural, Senokot, Senokot Granules, SenokotXTRA, Senolax, Sure-Lax (UK)

Pharmacologic class: Anthraquinone laxative

Therapeutic class: Laxative (stimulant)

Pregnancy risk category C

Action

Causes local irritation in colon, which promotes peristalsis and bowel evacuation. Softens feces by increasing water and electrolytes in large intestine.

Availability

Granules: 15 mg/tsp

Liquid: 8.8 mg/5 ml, 25 mg/5 ml, 33.3 mg/ml (concentrate)

Tablets: 8.6 mg, 10 mg, 15 mg, 17 mg, 25 mg

Strips (orally disintegrating): 8.6 mg

Tablets (chewable): 10 mg, 15 mg

Indications and dosages

Acute constipation; preparation for bowel examination

Adults and children ages 12 and older: For acute constipation, 12 to 50 mg P.O. daily or b.i.d. For bowel preparation, 105 to 157.5 mg (concentrate) 12 to 14 hours before scheduled procedure.

Children ages 6 to 11: 50% of adult dosage. Or, two orally disintegrating strips; don't exceed four strips in 24 hours.

Children ages 2 to 5: 33% of adult dosage. Or, one orally disintegrating strip; don't exceed two strips in 24 hours.

Contraindications

• Hypersensitivity to drug or its components

• GI bleeding or obstruction

• Suspected appendicitis or undiagnosed abdominal pain

• Acute surgical abdomen

• Fecal impaction

• Inflammatory bowel disease (such as Crohn's disease)

Precautions

Use cautiously in:

• pregnant or breastfeeding patients

• children.

Administration

• Give with a full glass of cold water.

• To prepare patient for bowel examination, give 12 to 14 hours before procedure, followed by a clear liquid diet.

Adverse reactions

GI: nausea, vomiting, diarrhea, abdominal cramps, nutrient malabsorption, yellow or yellowish-green feces, loss of normal bowel function (with excessive use), dark pigmentation of rectal mucosa (with long-term use), protein-losing enteropathy

GU: reddish-pink discoloration of alkaline urine, yellowish-brown discoloration of acidic urine

Metabolic: electrolyte imbalances (such as hypokalemia)

Other: laxative dependence (with long-term or excessive use)

Interactions

Drug-diagnostic tests. Calcium, potassium: decreased levels

Patient monitoring

• Assess bowel movements to determine laxative efficacy.

• In long-term use, monitor fluid balance, nutritional status, and electrolyte levels and watch for laxative dependence.

Patient teaching

• Tell patient using drug for constipation to take at bedtime with a glass of water.

• Instruct patient to place orally disintegrating strips on the tongue, allow strip to dissolve, then drink plenty of water.

• In long-term use, advise patient to watch for and report signs and symptoms of nutritional deficiencies and fluid and electrolyte imbalance.

• If patient will undergo bowel examination, advise him to take drug 12 to 14 hours before procedure, followed by a clear liquid diet.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

sen·na

(sen'ă),
The dried leaflets or legumes of Cassia acutifolia (Alexandrine senna) and C. angustifolia (Tinnevelly or Indian senna); a laxative.
[Ar. senā]

senna

(sĕn′ə)
n.
1. Any of various plants in the pea family, chiefly of the genera Senna and Chamaecrista, having pinnately compound leaves and showy, nearly regular, usually yellow flowers, used as ornamentals and for medicinal purposes.
2. A preparation of the dried leaves of Senna alexandrina, used as a laxative.

senna

Herbal medicine
A shrub native to northern and eastern Africa, which contains emodin and anthraquinone glycosides (sennosides A and B); it is primarily used as a laxative.
 
Toxicity
In excess, senna may evoke nausea, vomiting and colic; it should not be used in pregnancy or in those who are nursing, or who have colitis, haemorrhoids or ulcers. Overuse may be associated with so-called lazy bowel syndrome.

senna

A stimulant laxative drug used to treat constipation. The drug is on the WHO official list. A brand name is Senokot.
References in periodicals archive ?
It is important to note that in addition to ensuring the full development of students, working with socio-emotional skills also contributes to improving their performance in various subjects, such as mathematics, for example,' says Viviane Senna, President of the Ayrton Senna Institute.
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Ayrton Senna was the last driver to die at an F1 World Championship Grand Prix.
Ayrton Senna's nephew, Bruno Senna, of whom Ayrton was once quoted saying: 'If you think I'm fast just wait until you see my nephew Brun' will be carrying on his uncle's legacy this year as he makes his Formula 1 debut.
New team Hispania field Ayrton Senna's nephew Bruno Senna along with fellow F1 rookie Karun Chandhok, but they failed to finish their car in time to participate in the winter running and Boyles quote 8-1 that both drivers will complete Sunday's race.
Mercado Produtor da Barra, Avenida Ayrton Senna 1.791.
Best bets, however, are the more reflective Bones Of Angels, Tell Me There's A Heaven and Saudade - Rea's tribute to the late race ace, Ayrton Senna.
Ayrton Senna, after whom the car is named and who was killed in a crash in 1994, raced for McLaren from 1988 to 1993, winning three Formula One World Championships in the process.
behind team-mate Nico Rosberg last year, while he was vying for the lead with Nico Hulkenberg in his final race with McLaren in 2012 before a race-ending collision The Briton has said he wants to win as a tribute to his hero Ayrton Senna.
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TWENTY years after the death of Formula 1 legend Ayrton Senna, the car which launched the Brazilian's career is being put up for grabs.