In neurocompression syndromes in which the nerves have difficulties in accommodating themselves inside the neural canal during wide upper limb motion, the neural blood supply and axoplasmic flow
are reduced, resulting in the formation of connective tissue in structures adjacent to the nerve and in the nerve tissue itself.
It is a microtubule depolymerizing agent and causes blocking of the axoplasmic flow
in colchicine induced rat model of Alzheimer Disease (cAD) [1, 2].
These represent accumulations of neuronal organelles (chiefly mitochondria) in areas where neuronal axoplasmic flow
has been affected by losal ischaemia.
Even though the pathogenesis remains obscure, it is thought that alteration in the axoplasmic flow
of ganglion cells is the possible underlying reason.
When there is high pressure of the CSF, the pressure extends around the optic nerve and results in obstruction of the axoplasmic flow
in the optic nerve axons.
(7,8) Methotrexate-induced disruption of anterograde axoplasmic flow
may cause axonal accumulation of [beta]-APP, a constituent neuronal transmembrane glycoprotein.