Axid


Also found in: Dictionary, Acronyms.
Related to Axid: axis, Axid AR

Axid

 [ak´sid]
trademark for preparations of nizatidine, an antagonist of histamine H2receptors used to inhibit gastric acid secretion.

nizatidine

Apo-Nizatidine, Axid, Axid AR, Dom-Nizatidine, Gen-Nizatidine, Novo-Nizatidine, PHL-Nizatidine, PMS-Nizatidine, Zinga (UK)

Pharmacologic class: Histamine2 (H2)-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B

Action

Inhibits histamine action at H2-receptor sites in gastric parietal cells, reducing gastric acid secretion and pepsin production

Availability

Capsules: 150 mg, 300 mg

Oral solution: 15 mg/ml

Tablets: 75 mg

Indications and dosages

Active duodenal ulcer Adults: 300 mg P.O. daily at bedtime or 150 mg b.i.d. for up to 8 weeks

Maintenance of healed duodenal ulcers

Adults and children ages 12 and older: 150 mg P.O. daily at bedtime for up to 1 year

Esophagitis and associated heartburn caused by gastroesophageal reflux disease (GERD)

Adults: 150 mg P.O. b.i.d. for up to 12 weeks

Active benign gastric ulcer Adults: 150 mg P.O. b.i.d. or 300 mg P.O. once daily at bedtime

Erosive esophagitis; GERD

Children ages 12 and older: 150 mg P.O. b.i.d. for up to 8 weeks

Dosage adjustment

• Moderate to severe renal impairment

• Elderly patients

Contraindications

• Hypersensitivity to drug or other H2-receptor antagonists

Precautions

Use cautiously in:

• mild renal impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 (safety and efficacy not established).

Administration

• Give with or without food.

• If patient is to take drug twice daily, give one dose in morning and one at bedtime.

Adverse reactions

CNS: dizziness, drowsiness, headache, anxiety, nervousness, insomnia, abnormal dreams, asthenia

CV: chest pain

EENT: amblyopia, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, flatulence, anorexia, dry mouth

Hematologic: anemia

Musculoskeletal: back pain, myalgia

Respiratory: cough

Skin: rash, pruritus

Other: tooth disorder, infection, fever, pain

Interactions

Drug-drug. Salicylates (high doses): increased salicylate blood level

Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase: elevated levels

Urobilinogen tests using Multistix: false-positive result

Drug-herbs. Pennyroyal: altered rate of herbal metabolite formation

Patient monitoring

• Monitor liver and renal function tests.

• Check temperature; watch for fever and other signs and symptoms of infection.

Patient teaching

• Advise patient to take once-daily dose at bedtime with or without food, or twice-daily doses in morning and at bedtime.

• Instruct patient to take exactly as prescribed. Caution him not to take other OTC drugs (especially aspirin).

• Tell patient to report signs and symptoms of infection.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

Axid

(ăk′sĭd)
A trademark for the drug nizatidine.

nizatidine

A H2-receptor antagonist used to treat peptic ulcer disease.
 
Adverse reactions
Diarrhoea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynaecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis.

Axid®

Nizatidine, see there.

Axid

A brand name for NIZATIDINE.
References in periodicals archive ?
Physicians are cautioned to reduce the dose of AXID Oral Solution in any patients with moderate to severe kidney disease.
More serious cases of GERD may require stronger medications, the most common of which are histamine type 2 receptor antagonists (H2-hlockers), such as prescription-strength Axid, Pepcid, Tagamet and Zantac, and proton pump inhibitors (PPIs), such as Prevacid, Prilosec, Nexium, and Aciphex.
TABLE 5 Histamine 2 receptor antagonists and proton pump inhibitors in the US (34) Generic name Brand name [H.sub.2]RAs Cimetidine (a,b) Tagamet (35) Famotidine (b) Pepcid (36) Nizatidine (a,b) Axid (37) Ranitidine (a,b) Zantac (38) PPIs Dexlansoprazole Kapidex (25) Esomeprazole magnesium Nexium (23) Lansoprazole (b) Prevacid (20) Omeprazole magnesium (a,b) Prilosec (21) Omeprazole with sodium bicarbonate Zegerid (26) (immediate release) Pantoprazole (a) Protonix (22) Rabeprazole sodium AcipHex (24) (a) Available in generic form.
The medications belong to a class of drugs called histamine-2 receptor antagonists (H2A), and they include products such as Pepcid, Zantac, Axid, and Tagamet.
Because antacids are only effective for a short period, histamine -2 antagonists, like cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid), are often used for more frequent symptoms of as acid reflux.
H2 Blockers--Tagamet HB, Pepcid AC, Axid AR and Zantac 75 provide short-term relief, but should not be used for more than a few weeks at a time.
These agents, used for heartburn and GERD, include the histamine [H.sub.2] antagonists cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) and the proton pump inhibitors esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex).
The company markets a portfolio of products including: Lescol (fluvastatin) and Lescol XL (extended release tablets) for cholesterol management under an exclusive promotion agreement with Novartis Pharmaceuticals Corporation; DynaCirc (isradipine) and DynaCirc CR (an extended release formulation) for the treatment of hypertension; and Axid (nizatidine) for the treatment of GERD and peptic ulcers.
Pepcid (famotidine), Tagamet (cimetidine), Axid (nizatidine), and Zantac (ranitidine) make your stomach secrete less acid.
"Add to this Zantac 75 and the OTC version of Axid from American Home Products, which was launched this year, and you have more attention on the category," says Tom Quinn, vice president of sales, Warner-Wellcome, Parsippany, N.J., maker of Zantac 75.
This would help to ensure equivalent practices and technologies in home axid host countries.
H2 blockers include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac).