It has been suggested that apomorphine-induced hyperactivity is induced because of desensitisation of dopamine autoreceptors
Synaptic transmission by endogenous neurotransmitters via autoreceptors
or heteroreceptors is modulated within neuronal circuits.
2] muscarinic autoreceptors
involves endogenous adenosine activating [A.
2] receptors, which are inhibitory autoreceptors
, (33) thus the net effect is lower noradrenaline efflux.
At low doses Levosulpiride blocks dopamine autoreceptors
and facilitate dopaminergic neurotransmission.
5,6) Also, by blocking muscarinic autoreceptors
, scopolamine results in an acute upregulation of acetylcholine release, which, in turn, influences the nicotinic, dopamine, serotonin, and neuropeptide Y systems.
Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors
with dopamine transporters to reduce dopamine uptake," Neurobiology of Disease, vol.
In the brain, when the D2 autoreceptors
are activated, the dopamine release is reduced and this leads to decreased locomotor activity; however, when the postsynaptic D2 receptors are activated, the locomotion is slightly increased .
iDAN cells display sophisticated neuronal properties including pacemaking firing activity, synaptic integration, activity-dependent dopamine release and D2 functional autoreceptors
As a2-adrenoceptor agonist Dexmedetomidine can impact on the LC-Norepinephrine through adreno- autoreceptors
to regulate the body wakefulness; Dexmedetomidine can also regulate other awakening pathway activity by other adrenoceptors on other nerve terminals .
Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
Ginger facilitates cholinergic activity possibly due to blockade of muscarinic autoreceptors
in rat stomach fundus.