autoreceptor

(redirected from Autoreceptors)

au·to·re·cep·tor

(au'tō-rē-sep'tŏr, tōr),
A site on a neuron that binds the neurotransmitter released by that neuron, which then regulates the neuron's activity.
[auto- + receptor]
Farlex Partner Medical Dictionary © Farlex 2012

autoreceptor

A neurotransmitter receptor located in the presynaptic terminal of the same neuron that produces the neurotransmitter. Autoreceptors have a higher affinity for the neurotransmitter than does the postsynaptic receptor, and thus have an autoregulatory function.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

au·to·re·cep·tor

(aw'tō-rĕ-sep'tŏr)
A site on a neuron that binds the neurotransmitter released by that neuron, which then regulates the neuron's activity.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

au·to·re·cep·tor

(aw'tō-rĕ-sep'tŏr)
A site on a neuron that binds the neurotransmitter released by that neuron, which then regulates the neuron's activity.
[auto- + receptor]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Blockade of postsynaptic muscarinic receptors reduces the effects of acetylcholine, whereas blockade of presynaptic muscarinic autoreceptors causes an increase in acetylcholine release (4).
Posited mechanisms for the differences in acute versus chronic administration of SRIs include time required to achieve steady state concentrations in the CNS [33], desensitization of somatodendritic autoreceptors [34], and regulation of BDNF gene expression [35].
By a different mechanism, SSRIs increase serotonin by downregulating presynaptic [5HT.sub.1B] autoreceptors (5-hydroxytryptamine or serotonin) that can otherwise inhibit serotonin release [9], thereby increasing synaptic serotonin availability [6].
Of particular interest are D3 autoreceptors expressed in DA neurons [22]: PET imaging studies in humans using D3R-selective ligands showed that the ventral mesencephalon expresses mainly if not uniquely D3R [19, 23].
The primary role of [GABA.sub.B] receptors in the central nervous system is to function as autoreceptors for feedback regulation of synaptic GABA release.
Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat.
Since [m.sub.2]AChRs mediate the inhibition of voltage-sensitive [Ca.sup.2+] channels [21] that are known to be intimately involved in the regulation of neurotransmitter release, [m.sub.2]AChRs are considered the major inhibitory muscarinic autoreceptors in the mouse hippocampus and cerebral cortex [22].
Amisulpride has a high affinity for presynaptic D2 and D3 receptor subtypes at lower doses, with preference for limbic dopamine receptor together with affinity for dopamine autoreceptors, whereas at high doses it blocks the postsynaptic D2 receptors.
It has been suggested that apomorphine-induced hyperactivity is induced because of desensitisation of dopamine autoreceptors.17
Synaptic transmission by endogenous neurotransmitters via autoreceptors or heteroreceptors is modulated within neuronal circuits.
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