DNA sequencing

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Related to Automated DNA sequencing: Pyrosequencing

DNA sequencing

n.
The determination of the sequence of nucleotides in a sample of DNA.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

base-sequence analysis

A generally automated method for determining the order of nucleotide bases in a nucleic acid (DNA or RNA).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

DNA sequencing

The determination of the sequence of base pairs in a length of DNA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

DNA sequencing

determination of the order of NUCLEOTIDES in a DNA molecule or part thereof. A number of techniques is available to determine a DNA sequence, for example the chain-terminator DNA sequencing procedure (see DIDEOXYRIBONUCLEOTIDE). Generally such techniques rely on the power of polyacrylamide gels to resolve NUCLEIC ACID molecules that differ in length by only a single nucleotide. Ladders of DNA fragments are formed on the gels following ELECTROPHORESIS. Both manual and automated methods of sequencing are available.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
While the shotgun strategy is crucial to the new company's plans, Venter points out that the automated DNA sequencing machines just developed by Perkin-Elmer are equally important.
The amount of DNA received and its quality after PCR amplification (30 cycles) enabled automated DNA sequencing. The signal intensity was good (data not shown).
The genome of the isolate was analyzed for specific mutations in the pncA, oxyR, and gyrB genes by automated DNA sequencing, polymerase chain reaction--restriction fragment length polymorphism (PCR-RFLP) technique, and spoligotyping as described previously (5,12-16).
With the growth of high-throughput screening, automated combinatorial chemistry, microarrays and automated DNA sequencing, to name a few developments, the amount of data generated and analyzed is growing exponentially.
Commonwealth Biotechnologies, Inc., (Richmond, VA; 800-735-9224), a biotechnology contract research organization, announced that it has received a Notice of Allowance from the United States Patent and Trademark Office for its automated DNA sequencing reagent, AccuTrac, and the process for which it is used.
Although DNA sequencing is still considered the "gold standard" for characterizing specific nucleotide alterations and improved technology has made automated DNA sequencing available to the clinical molecular diagnostics laboratory, DNA sequencing remains too expensive and time-consuming for most applications.
Nucleotide sequence analysis was performed by using the OpenGene automated DNA sequencing system (Visible Genetics Inc., Toronto, Canada).
Visible Genetics manufactures and markets high performance automated DNA sequencing systems and complete diagnostic kits for the analysis of genes linked to disease.
Advances in automated DNA sequencing. Nature 1990;347:310.
CE&A will be paired with HVE's subsidiary, Physical Electronics, manufacturer of surface analysis instruments...Visible Genetics entered a four-year agreement with Organon Teknika, by which OT will be the exclusive distributor in Brazil for VGI's Open Gene automated DNA sequencing system and GeneKits.
Island hopping and similar proprietary advances in high-speed, automated DNA sequencing technology have given Myriad the ability to process large volumes of sequence data.
Although sequencing was long considered too cumbersome, expensive, and operator-dependent for use in the clinical laboratory, a combination of clinical need and improved technology has brought automated DNA sequencing into routine clinical use.

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