Evaluation of the optimized schemes for preoperative autologous donation
in cardiac elective surgery.
Currently, EPO treatment is widely used in treating anaemia caused by renal insufficiency, chemotherapy and HIV treatment, as well as preoperative autologous donation
to avoid infection by blood-borne diseases.
Private cord blood banks offer cord blood storage (autologous donation
) for personal use of donors and their family in consideration of an annual payment.
* Increased incidence of adverse reactions to autologous donation
effectively decreases postoperative ABT requirements but is not without risk.
* preoperative autologous donation
for minimising perioperative allogeneic blood transfusion ,
Out of fifty-four (46.5%) patients who were referred to the Department of Transfusiology, 46 patients donated blood and eight of them were denied autologous donation
because they did not satisfy the criteria; thus, 89 autologous blood units were collected, forty-two patients donated two units, each, and 4 patients donated one unit, each.
The advantages of preoperative autologous donation
include a decreased use of banked blood, stimulation of red blood cell production, a decrease in red blood cell loss intraoperatively (Lemos & Healy 1996, Anders et al 1996) found that preoperative donation of autologous blood is associated with a reduced incidence of postoperative deep vein thrombosis after total knee replacement.
is thought to be safer because of the risks associated with allogeneic blood transfusions, including transfusion-related acute lung injury which can lead to death, allergic reactions, transmission of infectious agents, and immunomodulatory effects (Moonen, Knoors, van Os, Verburg, & Pilot, 2007).
The donation is made without any restriction or direction regarding who may be the recipient of transplants of the cells derived, except in the case of autologous donation
No No 6.
Pre-operative autologous donation
of blood (PAD) for possible transfusion back to the patient (who is her/himself the donor) can be performed in the case elective surgery.
(8) The Society of Obstetricians and Gynaecologists of Canada Clinical Practice Guidelines, for example, state that "[c]ollection and long-term storage of umbilical cord blood for autologous donation
is not recommended because of the limited indications and lack of scientific evidence to support the practice." (9) The clinical utility of autologous storage is said to be limited because of the very low probability that an autologous hematopoietic stem cell transplant will be required by the individual in his/her lifetime, the uncertain shelf life of stored UCB, and the fact that autologous transplants are not recommended for inherited disorders or blood cancers.