The keratinized tissue condition is selected from the group consisting of acneiform eruptions, autoinflammatory syndromes
, chronic blistering, conditions of the skin appendages, dermatitis, drug or agent eruptions, infection-related, papulosquamous hyperkeratosis, palmoplantar keratodcrmas, pruritis, psoriasis, conditions resulting from physical factors, or ionizing radiation-induced conditions, according to the patent.
Inflammatory bowel disease--Crohn's disease, ulcerative colitis Hematologic disorders Hematologic malignancy Multiple myeloma Myelodysplasia Polycythemia vera Arthritis Rheumatoid arthritis Seronegative arthritis Inherited autoinflammatory syndromes
 PAPA PAPASH SAPHO AML, acute myeloid leukemia; PAPA, pyogenic arthritis, pyoderma gangrenosum, and acne; PAPASH, pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa; SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis.
Familial Mediterranean fever and the other autoinflammatory syndromes
: evaluation of the patient with recurrent fever.
It encompasses a spectrum of three clinically overlapping autoinflammatory syndromes
including familial cold autoinflammatory syndrome
, Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease.
Mutations in the inflammasome related genes can result in autoinflammatory syndromes
due to excess IL-1 .
: fever is not always a sign of infection.
Atteno et al., "Monogenic autoinflammatory syndromes
: state of the art on genetic, clinical, and therapeutic issues," International Journal of Rheumatology, vol.
In the recent years, the identification of genes involved in the modulation of inflammatory and apoptotic processes and the improved understanding of mechanisms linked to the aberrant activation of the inflammasome, a multi protein intracytoplasmatic scaffold complex synthesizing the biologically active interleukin-(IL-1), the prototypic master cytokine affecting nearly all cell types, have allowed the delineation of a new group of diseases called "monogenic autoinflammatory syndromes
are the sections in each chapter describing optimum treatment and treatment pitfalls and new sections on topics that include preventive medicine, atrial fibrillation, electrocardiography, gastrointestinal bleeding, and autoinflammatory syndromes
. The text is notable for the clarity of writing, which is in keeping with the supporting images, including the drawings presenting the clinical condition, tables, and color-coded algorithms.