autoimmune pancreatitis


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autoimmune pancreatitis

A condition characterised by diffuse enlargement of the pancreas and irregular stenosis of the main pancreatic duct (less commonly, also of the intrapancreatic bile duct on ERCP, associated with other autoimmune diseases).

Lab
Increased IgG4 autoantibodies.

Management
Corticosteroids.

autoimmune pancreatitis

Chronic pancreatitis, usually found in association with other autoimmune disorders (e.g., inflammatory bowel disease, rheumatoid arthritis, or Sjogren's syndrome). It is a relatively rare disease, suggested by the finding of antibodies against lactoferrin and carbonic anhydrase in the blood of affected patients. Biopsy specimens reveal infiltration of the organ by lymphocytes. It is treated with corticosteroids.
Synonym: autoimmune-related pancreatitis
See also: pancreatitis

autoimmune pancreatitis

Inflammation of the pancreas featuring an autoimmune process with obvious lymphocyte infiltration and fibrosis causing organ dysfunction. The disease takes a range of forms and includes conditions formerly known as chronic sclerosing pancreatitis, non-alcoholic duct-destructive chrinic pancreatitis, pseudotumerous pancreatitis and duct-narrowing chronic pancreatitis.
References in periodicals archive ?
T cells are increased in the peripheral blood of patients with IgG4-related autoimmune pancreatitis.
The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis.
Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis.
Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis.
Autoimmune pancreatitis versus pancreatic cancer: a comprehensive review with emphasis on differential diagnosis.
Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis.
Highly active state of autoimmune pancreatitis with mikulicz disease.
Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with autoimmune pathogenesis.
Typically, autoimmune pancreatitis (AIP) involves the entire pancreas and manifests as a diffusely enlarged, sausage-like gland with decreased attenuation on CT.
Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma.
The common causes of chronic pancreatitis include chronic alcohol abuse, idiopathic pancreatitis, hyperparathyroidism, hereditary pancreatitis, tropical pancreatitis, autoimmune pancreatitis and hypertriglyceridemia.

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