autoimmune inner ear disease


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autoimmune inner ear disease

an immune-mediated disease of the inner ear characterized by hearing loss, tinnitus, and vertigo.

autoimmune sensorineural hearing loss

A condition characterised by idiopathic, rapidly progressive, bilateral sensorineural hearing loss, which improves with corticosteroids and immunosuppressants. It is more common in women age 20 to 50.

Clinical findings
Bilateral sensorineural hearing loss which develops over weeks to months, with fluctuating symptoms, reduction in speech discrimination scores; vestibular symptoms occur in half of patients, and include disequilibrium, ataxia, motion intolerance, positional vertigo, and episodic vertigo; up to half of patients complain of tinnitus and aural fullness, and up to one-third have systemic autoimmune disease—e.g., rheumatoid arthritis, ulcerative colitis, systemic lupus erythematosus and polyarteritis nodosa.
References in periodicals archive ?
Vambutas, "IL-1[beta] is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease," Journal of Immunology, vol.
Harris, "Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study," Otology & Neurotology, vol.
Autoimmune inner ear disease. Curr Opin Otolaryngol Head Neck Surg 2004;12(5):426-30.
Autoimmune inner ear disease. American Hearing Research Foundation Web site.
Shipp et al., "Cochlear implantation in patients with autoimmune inner ear disease including Cogan syndrome: a comparison with age- and sex-matched controls," The Laryngoscope, vol.
(2,7,8) Several studies have also indicated a benefit from steroids in smaller numbers of patients with autoimmune inner ear disease, although no previous study has described their use specifically for treatment of VKH-syndrome-related SNHL.
We describe 2 cases of bilateral Meniere disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27.
The best overall responses were seen in 2 patients with Cogan's syndrome and 1 patient with clinical autoimmune inner ear disease. No case of treatment-induced hearing loss was seen, as auditory thresholds remained stable even in patients who did not respond to therapy.
It is possible that these patients had other etiologies (e.g., autoimmune inner ear disease) that contributed to their vertigo symptoms.
On the other hand, I know that some rheumatologists are very careful when they prescribe methotrexate or cyclophosphamide for autoimmune inner ear disease, and they obtain consent after a fairly detailed discussion.
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