autoantibody

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autoantibody

 [aw″to-an´tĭ-bod″e]
an antibody formed in response to, and reacting against, an antigenic constituent of the individual's own tissues.

au·to·an·ti·bod·y

(aw'tō-an'ti-bod-ē),
An antibody that occurs in response to antigenic constituents of the host's tissue (or "self antigen") and reacts with the inciting target tissue.

autoantibody

(ô′tō-ăn′tĭ-bŏd′ē)
n.
An antibody that reacts with the cells, tissues, or native proteins of the individual in which it is produced.

autoantibody

Any antibody produced by an organism against one of its own—self-antigens.

Autoantibodies
Examples of autoantibodies and disease associations
• Anti-actin antibodies—coeliac disease.
• Anti-centromere antibodies—CREST syndrome.
• Anti-ganglioside antibodies—acute motor neuronal neuropathy.
• Antimitochondrial antibody—primary biliary cirrhosis.
• Anti-neutrophil cytoplasmic antibody—Wegener’s granulomatosis (in neutrophil cytoplasm).
• Anti-neutrophil cytoplasmic antibody—Churg-Strauss syndrome, microscopic polyangiitis, systemic vasculitides (perinuclear location).
• Anti-nuclear antibodies (e.g., anti-SSA/Ro)—systemic lupus erythematosus.
• Anti-signal recognition peptide—polymyositis.
• Anti-smooth muscle antibody—chronic autoimmune hepatitis.
• Anti-glomerular basement membrane antibodies.
• Anti-parietal cell antibodies, and others.
• Anti-nuclear antibodies (ANA).
• Anti-smooth muscle actin (SMA).
• Anti-liver-kidney-microsomal antibody (LKM), 2 types:
   - Anti-mitochondrial (AMA);
   - Perinuclear antineutrophil cytoplasmic (pANCA).
• Anti-soluble liver antigen (SLA), other autoantibodies.
• ANA and SMAs are known to be positive in AIH, PBC, PSC, HCV, HBV, HDV, NASH, drug-induced hepatitis.

autoantibody

Immunology Any antibody produced by an organism against one of its own–self antigens. See Antibody, Hashimoto's thyroiditis, Lupus erythematosus, Myasthenia gravis, Rheumatoid arthritis.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.

autoantibody

An antibody derived from the immune system, which then acts against body tissues or constituents.

Autoantibody

An antibody produced by the body in reaction to any of its own cells or cell products.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.
References in periodicals archive ?
Thyroid autoantibodies in black and white children and adolescents with type 1 diabetes mellitus and their first-degree relatives.
The main underlying pathology is the presence of autoantibodies, and thrombocyte replacement is not enough alone to increase the platelet count due to the presence of autoantibodies (1).
Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: Analysis of 100 French Canadian patients.
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.
Detection of autoantibodies in the serum of primary hepatocarcinoma patients.
This is the first time that adalimumab was used to treat arthritis associated with JIIM and anti-MDA5 autoantibodies. The initial high doses of corticosteroids prevented the development of ILD and CNS disease but resulted in osteonecrosis.
[127] investigated whether anti-heart autoantibodies are directly pathogenic to the host by passive transfer of affinity-purified anti-heart autoantibodies from sera of patients with myocarditis to normal BALB/c mice to induce experimental myocarditis.
Despite differing hypersensitivity conditions, patients within these autoimmune subgroups may be more likely than their counterparts with the same hypersensitivity condition to have a positive autologous serum skin test (ASST), a marker of self reactivity; have autoantibodies (high affinity IgE receptor (Fcepsilon Rla aka FceRIa), IgE, or others) that may contribute to their conditions; and have more severe cases.
An important aspect of SLE is the presence of numerous self-antigen specific autoantibodies, principally of nuclear origin.
Recent studies have described disseminated NTM infection in patients in Asia with adult-onset immunodeficiency resulting from neutralizing anti-IFN-[gamma] autoantibodies (5-7).
The presence of CA autoantibodies has been documented in acute anterior uveitis, Graves' disease, systemic lupus erythematosus, Sjogren's syndrome, endometriosis, idiopathic chronic pancreatitis, primary biliary cirrhosis, tubulointerstitial nephritis, autoimmune hepatitis, and autoimmune cholangitis.
reported neurological autoantibodies (NAAs) among patients with epilepsy of unknown etiology.