Auto-antibodies

An antibody that is produced in, and reacts with, an antigen in the same person or animal.

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The primary and subgroup analyses show that satralizumab significantly reduces the risk of relapse in patients who were seropositive for aquaporin-4 auto-antibodies (AQP4-IgG), as well as the overall ITT population representative of NMOSD patients.

Roche to present pivotal data for satralizumab in neuromyelitis optica spectrum disorder and six-year OCREVUS data in multiple sclerosis at ECTRIMS

Provention is initially developing PRV-3279 for the interception of systemic lupus erythematosus (SLE), a chronic autoimmune disorder characterized by an abnormal overactivation of B cells and subsequent pathologic production of auto-antibodies. PRV-3279 also has the potential to prevent or reduce the immunogenicity of biotherapeutics, including but not limited to gene therapy vectors and transgenes.

Provention Bio Initiates Phase 1b/2a PREVAIL Clinical Trial Evaluating PRV-3279 in Lupus

Complement activation by anti-AQP4 auto-antibodies can cause destruction of vital cells in the CNS, leading to demyelination and to the death of neurons, predominantly in the spinal cord and optic nerve.

Alexion Receives Positive CHMP Opinion for SOLIRIS (eculizumab) for the Treatment of NMOSD

Food and Drug Administration (FDA) approved SOLIRIS[R] (eculizumab) for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.1 Approximately three quarters (73%) of all patients with NMOSD test positive for anti-AQP4 auto-antibodies.2 The FDA approved SOLIRIS following an expedited six-month priority review.

Alexion Pharmaceuticals (NASDAQ: ALXN) - Alexion Receives FDA Approval Of SOLIRIS[R] (Eculizumab) For The Treatment Of Adults With Neuromyelitis Optica Spectrum Disorder (NMOSD) Who Are Anti-Aquaporin-4 (AQP4) Antibody Positive -- 27/6/2019

Isaacs' syndrome is a rare neuromuscular disorder, characterized by hyperexcitability of the peripheral nerves and continuous activation of muscle fibers, due to auto-antibodies directed against the voltage-gated potassium channels (1).

Spontaneous Remission of Isaacs' Syndrome

Approximately three quarters of all patients with NMOSD test positive for anti-AQP4 auto-antibodies, the company said.

Alexion confirms FDA approval of Soliris for treatment of NMOSD

The median level of antidesmoglein Auto-antibodies fell by up to 65%.

BTK inhibitor calms pemphigus vulgaris

They were especially interested in the 969 seropositive (as opposed to seronegative) patients, who have auto-antibodies related to the disease and generally have more severe symptoms, including joint deformities and disability.

Quitting smoking may reduce rheumatoid arthritis risk

Female Infertility and Serum Auto-antibodies: a Systematic Review.

Evaluation of the Ovarian Reserve in Adolescents with Hashimoto's Thyroiditis Using Serum Anti-Mullerian Hormone Levels

Primary Sjogren's syndrome (pSS) is a chronic autoimmune connective tissue disorder characterized by sicca symptoms and circulating auto-antibodies (usually anti-SSA/Ro or anti-SSB/La) affecting 0.3%-0.5% of the Western population, and it is known to be prevalent in females (9:1) (1).

Anti-Ro antibodies and complete heart block in adults with Sjogren's syndrome

Moreover, malignant diseases may trigger generation of auto-antibodies against a wide range of antigens as a result of immune dys-regulation.

An elusive case of digital ischemia in a patient with Rheumatoid Arthritis

The nature of the thyroid auto-antibodies present in patients with Hashimoto's thyroiditis (lymphadenoid goitre).