The primary and subgroup analyses show that satralizumab significantly reduces the risk of relapse in patients who were seropositive for aquaporin-4
auto-antibodies (AQP4-IgG), as well as the overall ITT population representative of NMOSD patients.
Provention is initially developing PRV-3279 for the interception of systemic lupus erythematosus (SLE), a chronic autoimmune disorder characterized by an abnormal overactivation of B cells and subsequent pathologic production of
auto-antibodies. PRV-3279 also has the potential to prevent or reduce the immunogenicity of biotherapeutics, including but not limited to gene therapy vectors and transgenes.
Complement activation by anti-AQP4
auto-antibodies can cause destruction of vital cells in the CNS, leading to demyelination and to the death of neurons, predominantly in the spinal cord and optic nerve.
Food and Drug Administration (FDA) approved SOLIRIS[R] (eculizumab) for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.1 Approximately three quarters (73%) of all patients with NMOSD test positive for anti-AQP4
auto-antibodies.2 The FDA approved SOLIRIS following an expedited six-month priority review.
Isaacs' syndrome is a rare neuromuscular disorder, characterized by hyperexcitability of the peripheral nerves and continuous activation of muscle fibers, due to
auto-antibodies directed against the voltage-gated potassium channels (1).
Approximately three quarters of all patients with NMOSD test positive for anti-AQP4
auto-antibodies, the company said.
The median level of antidesmoglein
Auto-antibodies fell by up to 65%.
They were especially interested in the 969 seropositive (as opposed to seronegative) patients, who have
auto-antibodies related to the disease and generally have more severe symptoms, including joint deformities and disability.
Female Infertility and Serum
Auto-antibodies: a Systematic Review.
Primary Sjogren's syndrome (pSS) is a chronic autoimmune connective tissue disorder characterized by sicca symptoms and circulating
auto-antibodies (usually anti-SSA/Ro or anti-SSB/La) affecting 0.3%-0.5% of the Western population, and it is known to be prevalent in females (9:1) (1).
Moreover, malignant diseases may trigger generation of
auto-antibodies against a wide range of antigens as a result of immune dys-regulation.
The nature of the thyroid
auto-antibodies present in patients with Hashimoto's thyroiditis (lymphadenoid goitre).