Hutter G, Nowak D, Blau IW, Thiel E: Auer rod
like intracytoplasmic inclusions in multiple myeloma.
In one survey, the CAP received the following five different identifications on a hematology slide: segmented neutrophil, Auer rod
, toxic granulation, Barr body, and Dohle inclusion body.
A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and "splinter-type" Auer rods
0% Platelets 30 K/[mu]L 150-450 K/[mu]L Differential Neutrophils 3% 33-61% Lymphocytes 10% 25-45% Blasts 87% 0% Nucleated RBC's 2 RBC Morphology Polychromasia WBC Morphology Auer rods present D-Dimer 18.
3), (5) The presence of Auer rods is also a significant clue.
Occasional blasts, especially the more mature forms, may contain blunted Auer rods (Figure B).
The myeloid blasts in t(8; 21) AML are large, with abundant basophilic cytoplasm, with perinuclear hofs, occasional to numerous azurophilic granules, and blunted Auer rods.
Hypergranular acute promyelocytic leukemia (APL): The most common morphologic variant of APL, representing approximately 75% of cases, is characterized by bone marrow containing large, abnormal promyelocytes with pleomorphic nucleoi and cytoplasm containing coarse, large granules with abundant Auer rods
, often in bundles.
The cells of acute granulocytic leukemia have been reported to contain a variety of inclusions, including Auer rods, "hexagonal" or "light green" crystals, pseudo-Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
Acute granulocytic leukemia may contain a variety of intracellular inclusions, including Auer rods, hexagonal or light green crystals, pseudo--Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
Morphological tinclings of pathological "clonal" blasts (type II that contain Auer rods
, Pseudo-Chediak-Higashi or other specific inclusions that are not seen in reactive marrow) refer to the diagnosis of RAEB-2 or AML; here again the arbitrary cut-off point of 20% blasts results in a specific diagnosis.
The crystalline structures were believed to be reminiscent of Auer rods