Phenelzine versus imipramine in the treatment of probable atypical depression
: defining syndrome boundaries of selective maoi responders.
As for the research on chromium picolinate and the atypical depression
cycle, Davidson investigated Zeramax[TM], a chromium picolinate-based supplement from Nutrition 21, as a proprietary nutrition therapy for depression.
Particular interest in this construct grew from studies that suggested that atypical depression
is more responsive to a monoamine oxidase inhibitor (MAOI) than to a TCA, but also that SSRIs are not dearly superior to MAOI.s.(17) Response to ECT might also be better in atypical than in typical depression.(18)
Monoamine oxidase inhibitors in the treatment of atypical depression
. J Clin Psychopharmacol 1985; 5:131-7.
Concerns about side effects--primarily hypertensive crisis--and dietary restrictions have lead many clinicians to curtail their use of MAOls, but increased knowledge of these drugs can help psychiatrists reconsider this treatment option, particularly for patients with atypical depression
Those patients could benefit from using monoamine oxidase (MAO) inhibitors, since those drugs are most effective in atypical depression
or hysteroid dysphoria, which often occurs with irritability, sensitivity to rejection, loneliness, anger, and eating and sleeping too much.
Akiskol and Benazzi (35) suggest that atypical depression
may be a subtype of the bipolar spectrum.
Less-frequent diagnoses in the arrest group included atypical depression
(five subjects), schizophrenia or borderline personality disorder (three subjects each), and schizophreniform disorder, bipolar affective disorder, or major depression (two subjects each).
Connor of Duke University in Durham, N.C., reported positive results in the open-label phase of a trial evaluating modafinil for atypical depression
Many psychiatrists equate atypical depression
with conditions such as hyperphagia and hypersomnia.
"That constellation of symptoms known as atypical depression
seems to preferentially respond to our old friends--the MAO inhibitors," Dr.