atypical antipsychotic

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atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
 
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
 
Examples
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).

antipsychotic

(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
References in periodicals archive ?
Atypical antipsychotics are much better than the conventional antipsychotic and do not cause extra pyramidal symptoms.
However, the largest study to date showed no significant difference in rates of major congenital malformations for those with one or more prescriptions for atypical antipsychotics in the first trimester, compared with pregnancies with no first-trimester antipsychotic exposure.
Researches to develop more effective drugs became the basis for development of atypical antipsychotics. The fast dissociation with the D2 receptors, 5-HT2a antagonism and 5-HT1a agonism are the unique features which make these drugs better than the conventional, standard antipsychotics (Lind et al., 2005).
Among atypical antipsychotics risperidone and amisulpride affect prolactin levels more frequently while clozapine, olanzapine, quetiapine are prolactin-sparing2,3.
IANS | Toronto While there is a growing need to reduce antipsychotic use, trazadone -- a drug frequently used as an alternative -- is associated with similar risk of falls and major fractures in elderly as atypical antipsychotics, warns a new study.
Treatment of bipolar disorder frequently includes mainstay treatment with mood stabilizers such as sodium valproate, lithium, lamotrigine, and second-generation atypical antipsychotics. While we have robust information regarding the reproductive safety of sodium valproate, it is a teratogen with a very high risk for neural tube defects.
The researchers focused on five atypical antipsychotics: aripiprazole, ziprasidone, quetiapine, risperidone, and olanzapine.
NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drugs.
Most antipsychotics exposed were atypical antipsychotics (77.3%).
Impaired neuroplasticity in schizophrenia and the neuro-regenerative effects of atypical antipsychotics. Medscape Psychiatry, http:// www.medscape.org/viewarticle/569521.
About 1.5% of children treated with two or more drugs received two atypical antipsychotics, and 0.6% were prescribed two stimulant classes.