atypical squamous cells of undetermined significance


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atypical squamous cells of undetermined significance (ASCUS),

the term in the Bethesda system for reporting cervical/vaginal cytologic diagnosis describing cellular abnormalities that are more marked than those attributable to reactive changes but that quantitatively or qualitatively fall short of a definitive diagnosis of low-grade squamous intraepithelial lesion; may reflect a benign or a potentially serious lesion.
See also: Bethesda system, reactive changes.

a·typ·i·cal squa·mous cells of un·de·ter·mined sig·nif·i·cance

(ASCUS) (ā-tip'i-kăl skwā'mŭs sel zŭn-dĕ-tĕr'mind sig-nif'i-kăns)
The term in the Bethesda system for reporting cervical-vaginal cytologic diagnosis describing cellular abnormalities that are more marked than those attributable to reactive changes but that quantitatively or qualitatively fall short of a definitive diagnosis of squamous intraepithelial lesion (SIL); may reflect a benign or a potentially serious lesion.
See also: Bethesda system, reactive changes
References in periodicals archive ?
Diagnosis of cases based on cytology Broad cytology Details of cytology Number diagnosis (N) diagnosis of cases Unsatisfactory * (5) 5 Negative ** (95) Normal 4 Inflammation (non-specific) 88 Inflammation (specific) (+) 3 Squarnous epithelial ASC-US 7 lesions (33) ASC-H 3 AGUS 2 L-SIL 5 H-SIL 16 Total (133) 133 * Cases with scant, non-representative smear ** Cases negative for epithelia] lesions (+) Of the 3 cases, 2 had Trichomonas vaginalis and 1 had Candida infection ASC-IS, atypical squamous cells of undetermined significance ASC-H, ?
Reduction in poor quality specimens using the thin-layer method Thin-layer Conventional smears (n = 18,712) (n = 11,521) % Change Less than optimal 2,419 (13%) 2,876 (25%) -48.0 Unsatisfactory 4 (0.02%) 32 (0.28%) -92.9 Diagnostic detection rates of thin-layer versus conventional screening Thin-layer Conventional smears (n = 18,712) (n = 11,521) % Change ASCUS 451 (2.4%) 272 (2.4%) 0 LGSIL 759 (4.06%) 152 (1.32%) +207.6 HGSIL 366 (1.96%) 111 (0.96%) +104.2 ASCUS:SIL ratio 0.40 0.84 -52.4 ASCUS = atypical squamous cells of undetermined significance; SIL = squamous intraepithelial lesions; LGSIL = low-grade squamous intraepithelial lesions; HGSIL = high-grade squamous intraepithelial lesions.
Cytologic-Histologic Correlation for Anal Papanicolaou Tests (January 2013 to June 2015) Bx dx/Pap Unsat, % NILM, % ASC-US, % (n = 38) (n = 73) (n = 60) Negative 31.6 34.2 25 LSIL 57.9 57.3 63 HSIL 10.5 6.8 10 SCC 0 1.4 1.7 Bx dx/Pap LSIL, % ASC-H, % HSIL, % (n = 130) (n = 14) (n = 61) Negative 11.5 35.7 13 LSIL 64.5 50.0 36 HSIL 21.5 14.3 46 SCC 1.5 0 5 Abbreviations: ASC-H, atypical squamous cells, cannot exclude HSIL; ASC-US, atypical squamous cells of undetermined significance; Bx dx, biopsy diagnosis; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy; Pap, Papanicolaou smear diagnosis; SCC, squamous cell carcinoma; Unsat, unsatisfactory.
The 3%-5% of all tested cases are classified as ASCUS (Atypical Squamous Cells of Undetermined Significance) and another 3%-5% are reported as low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) or cervical intraepithelial neoplasia (CIN).
Ten (9.8%) cases showed atypical squamous cells of undetermined significance (ASCUS) and four (3.9%) cases had atypical glandular cells of undetermined significance (AGUS).
The guidelines confirm that the HPV test is an appropriate tool in the management of atypical squamous cells of undetermined significance (ASC-US) among women 21 years and older and as a cotest with the Pap for women who are 30 years and older.
One woman with persistent HPV in this middle-age group developed atypical squamous cells of undetermined significance (ASCUS).
Detecting Abnormal Cytology With Self- and Clinician-Collected Samples Sensitivity Specificity Self Clinician Self Clinician ASCUS 0.70 0.70 0.62 0.66 LSIL 0.63 0.63 0.56 0.60 Notes: ASCUS, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesions.
Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: Baseline results from a randomized trial.
The category of squamous cell abnormality includes the subcategories of atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and squamous cell carcinoma.

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