atypical small acinar proliferation


Also found in: Acronyms.

atypical small acinar proliferation (prostate)

A small prostate acinus or acini with abnormal or atypical glands that have insufficient cytological or architectural atypia for a definitive diagnosis of cancer. ASAPs are seen in ±5.5% of patients undergoing needle biopsies of the prostate, in whom cancer is identified in 40–50% on subsequent biopsy.
 
Management
ASAP is probably best managed with active surveillance.
References in periodicals archive ?
Atypical small acinar proliferation reflects a broad group of prostate lesions with insufficient changes in the cells to definitively diagnose prostate cancer.
Recommendations: Atypical small acinar proliferation lesions are cancerous until proven otherwise and should undergo repeat biopsy (Grade B recommendation).
Prognostic significance of high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation in the contemporary era.
Subsequent prostate cancer detection in patients with prostatic intraepithelial noeplasia or atypical small acinar proliferation.
Atypical small acinar proliferation suspicious for malignancy in prostate needle biopsies: clinical significance in 33 cases.
Cases falling short of the threshold for the diagnosis of carcinoma are often descriptively diagnosed as atypical small acinar proliferations.
Collagenous micronodules have not been reported in benign glands, benign prostatic hyperplasia, or prostatic intraepithelial neoplasia, but Iczkowski and Bostwick (14) described them in 2% of the cases they had diagnosed as atypical small acinar proliferations.
The presence of glands in a perineural location used to be considered tantamount to a diagnosis of malignancy, (13) but it has been reported with benign acini (39) and in atypical small acinar proliferations as well.
How many sections of breast core needle biopsy specimens are necessary to ensure that all atypical ductal hyperplasia lesions and atypical small acinar proliferations are sampled?
Biopsies were performed on both atypical small acinar proliferations for mass lesions.
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