atypical small acinar proliferation


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atypical small acinar proliferation (prostate)

A small prostate acinus or acini with abnormal or atypical glands that have insufficient cytological or architectural atypia for a definitive diagnosis of cancer. ASAPs are seen in ±5.5% of patients undergoing needle biopsies of the prostate, in whom cancer is identified in 40–50% on subsequent biopsy.
 
Management
ASAP is probably best managed with active surveillance.
References in periodicals archive ?
Atypical small acinar proliferation reflects a broad group of prostate lesions with insufficient changes in the cells to definitively diagnose prostate cancer.
Recommendations: Atypical small acinar proliferation lesions are cancerous until proven otherwise and should undergo repeat biopsy (Grade B recommendation).
Criteria for biopsy diagnosis of minimal volume prostatic adenocarcinoma: analytic comparison with nondiagnostic but suspicious atypical small acinar proliferation. Arch Pathol Lab Med.
Two critical histological diagnoses that are predictive of an underlying prostatic adenocarcinoma are atypical small acinar proliferations (ASAP), also referred to as ATYP, and high-grade prostatic intraepithelial neoplasia (HGPIN).
These findings may include precancerous conditions, such as high-grade prostatic intraepithelial neoplasia (PIN) or atypical small acinar proliferations (atypia).
These features are the finding of (1) high-grade prostatic intraepithelial neoplasia, or (2) atypical small acinar proliferations. Other possible--but as of now not well defined--features of concern are atypical adenomatous hyperplasia, post-atrophic hyperplasia, and proliferative inflammatory atrophy.
How many sections of breast core needle biopsy specimens are necessary to ensure that all atypical ductal hyperplasia lesions and atypical small acinar proliferations are sampled?
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