atypical lobular hyperplasia


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atypical lobular hyperplasia

A relatively uncommon lesion of the female breast characterised by lobules containing uniform dyshesive epithelial cells with eccentric nuclei, often accompanied by intracytoplasmic mucin vacuoles (so-called“private acini”); the surrounding myoepithelial cell layer is retained. It is a non-palpable lesion seen in 1% to 3.6% of female breasts and carries a general increase in the risk of future breast cancer.
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In contrast, breast cancer risk in women with atypical lobular hyperplasia remained steady over time.
That worked out to an adjusted odds ratio for developing breast cancer of 2.76 for women with atypical ductal hyperplasia, 5.24 for those with atypical lobular hyperplasia, and 8.12 for women with both histologic abnormalities, she continued.
An MMP-9-positive / ADAM 12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia.
An MMP-9-positive/ADAM12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia. And a sample that proved negative for both biomarkers was associated with a zero probability of atypical hyperplasia.
Atypical lobular hyperplasia was diagnosed when acini in a lobular unit had less than 50% involvement by a monotonous population of epithelial cells showing classic lobular characteristics, including discohesive cells with small, round nuclei, often containing perinuclear vacuoles.
The term lobular neoplasia has been applied to the spectrum of lesions comprising atypical lobular hyperplasia (ALH) and LCIS.
Age distributions of patients with carcinoma, atypical ductal hyperplasia (ADH), and atypical lobular hyperplasia (ALH).
Malignant (18%; 31/177) Invasive ductal carcinoma 13 Invasive lobular carcinoma 4 Ductal carcinoma in situ 12 Invasive mixed carcinoma 1 Tubular carcinoma 1 Atypical epithelial hyperplasia (11%; 20/177) Atypical ductal hyperplasia 3 Lobular neoplasia 17 (12 ALH, 5 LCIS) Benign (71%;126/177) Benign breast diagnoses (105/126) Fibrocystic changes with/without 31 epithelial hyperplasia Columnar cell lesions 30 Fibroadenoma and 14 fibroadenomatoid change Ductal ectasia 7 Radial sclerosing lesion 6 Papilloma 7 PASH 5 Intramammary lymph node 3 Fat necrosis 1 Hemangioma 1 Normal breast tissue (21/126) Abbreviations: ALH, atypical lobular hyperplasia; LCIS, lobular carcinoma in situ;PASH, pseudoangiomatous stromal hyperplasia.
The atypia category included ADH, apocrine atypia, atypical lobular hyperplasia, and classic lobular carcinoma in situ.
(23) Lobular carcinoma in situ and/ or atypical lobular hyperplasia is associated with tubular carcinoma in approximately half of cases.
E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast.

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