16, 2019 (HealthDay News) -- An artificial intelligence program outperforms pathologists for differentiating ductal carcinoma in situ (DCIS) from atypia
, according to a study published online Aug.
Dr Joann Elmore, lead author of the study in the Jama Network Open journal, said: "Distinguishing breast atypia
from ductal carcinoma in situ (DCIS) is important clinically but very challenging for pathologists."
That earlier research revealed that diagnostic errors occurred in about one out of every six women who had ductal carcinoma in situ (a noninvasive type of breast cancer), and that incorrect diagnoses were given in about half of the biopsy cases of breast atypia
(abnormal cells that are associated with a higher risk for breast cancer).
In contrast to uVIN, dVIN often lacks full-thickness atypia
, and the moderate to marked cellular atypia
is only confined to the basal and parabasal cells of the epidermis (lower 2-3 layers of the epithelium).
Histopathology demonstrated a large cyst lined by either papillary projections or a single layer of cuboidal cells with mild to moderate atypia
and surrounding solid tumor nests with focal cribriform pattern [Figure 3a-c].
 Endometrioid endometrial carcinoma (EECA) accounts for three fourths of endometrial cancers and are believed to develop following a continuum of premalignant lesions ranging from endometrial hyperplasia without atypia
, to endometrial hyperplasia with atypia
and finally to well differentiated carcinoma.
Overall, 155 lesions were deemed positive for cancer or atypia
by RCM, while 1,034 were determined to be benign.
On macroscopic examination, the presence of dilatation and perforation, maximum diameter of the specimen, surgical border, and presence of mucin and on microscopic examination, the level of architectural and cytologic atypia
, intactness of the muscularis mucosa, submucosal fibrosis, hyalinization, presence of atrophy in the lymphoid tissue, presence of invasion pushing toward the appendiceal wall, desmoplasia, and presence of single cell invasion were examined by the same pathological experts, who then reached a consensus (Tables 3A, 3B).
In this case, the pathological diagnosis of resected thyroid neoplasm was initially AF by medical history, which is one kind of rare benign soft-tissue tumor (<3% in all soft-tissue tumor), and thyroid AF is very less frequent. Histopathologic examination of thyroid AF reveals that a spindle-cell proliferation with fibroblastic characteristics and with no atypia
and thin capillary vessels, and thyroid cells do not display any features of papillary thyroid cancer.
and Dupond et al., and containing the non-proliferative disease, proliferative disease without atypia
, and proliferative disease with atypia
A Pearson's chi square statistic was also performed to distinguish whether the presence of atypia
was a significant variable.