ATRA


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Related to ATRA: ATTRA, ATRA syndrome

ATRA

A vitamin-A analogue used to manage acute promelocytic leukaemia, with the translocation t(15;17) or typical PML-RAR gene rearrangement, as it prompts the leukaemic cells to maturation.

Adverse effects
Headaches, dry skin, mouth and eyes, nausea, bone pain.
References in periodicals archive ?
Besides talc litigation, ATRA also panned a Missouri Supreme Court ruling on May 22 that upheld a $19 million jury award for the widow of a man killed in a collision with a train.
Diffuse alveolar hemorrhage in acute promyelocytic leukemia patients treated with ATRA - A manifestation of the basic disease or the treatment.
All-transretinoic acid (ATRA), a vitamin A derivative, binds to the RARA site of the PML-RARA fusion protein in APL cells and allows the leukemic promyelocytes to differentiate into mature granulocytes.
Following this, the ATRA established a Code of Ethics in 1990 (six years after the start of the association), with the current revised version completed and adopted in 2009 (ATRA, 1998; 2009) (see Table 1).
atra extract needed to kill 50% and 90% of the treated larvae 24 hours post -treatment for this extract were 188.59 and 261.28 ppm consecutively, while the extract concentrations of the seagrass T.
The patient had a WBC count of 35,000 [micro]L at a visit to our hospital, and thus we commenced concomitant treatment with 45 mg/[m.sup.2]/day of ATRA and 12 mg/[m.sup.2]/day idarubicin (IDA), in accordance with GIMEMA-AIEOP protocol.
Under normal physiologic conditions, ATRA functions to cause ligand-dependent conformational changes in wildtype RARA that induce dissociation of the corepressors SMRT (silencing mediator of retinoid and thyroid hormones) or N-CoR (nuclear corepressor) so that cellular differentiation can proceed.
He said, It is an honor for PTA to be selected as trainer by ITU to impart training to ATRA".
As of March 2014, Afghanistan's mobile coverage reaches over 89 per cent of the country's population of 30 million, according to ATRA.
Tax Planning Opportunities After ATRA: Tools, Tips, and Tactics