TCIRG1

(redirected from Atp6i)

TCIRG1

A gene on chromosome 11q13.2 that encodes an osteoclast-specific H+-ATPase proton pump and multipass membrane protein that is part of the proton channel of V-ATPases, thought to be involved in T-cell activation.

Molecular pathology
Defects in TCIRG1 cause osteopetrosis autosomal recessive type 1 (autosomal recessive Albers-Schonberg disease).
References in periodicals archive ?
3), and the mRNA levels for TRAP and ATP6i were also increased (both P-values < 0.01; Fig.
But LPNS did not affect the levels of TRAP and ATP6i (data not shown), the staining of TRAP (Fig.
Moreover, LPNS decreased the mRNA levels of TRAP and ATP6i, which are classic markers of bone resorption.
LPNS did not affect the levels of TRAP and ATP6i, the staining of TRAP, or the bone resorption activity shown by differentiated osteoclasts.