ABC Superfamily

(redirected from Atp-binding cassette transporters)

ABC Superfamily

A family of oligopeptide permease proteins, which are selective for various substrates including short oligopeptides, transporting them across membranes.
Examples Multi-drug resistance protein, bacterial and eukaryotic transporters
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References in periodicals archive ?
Kroemer, "Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)," Drug Metabolism Reviews, vol.
New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications
Tall, "ATP-binding cassette transporters, atherosclerosis, and inflammation," Circulation Research, vol.
Wang et al., "Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice," Circulation Research, vol.
Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367
Firstly, cholesterol absorption from daily diet is mainly depended on Niemann-Pick C1-Like 1 (NPC1L1) and ATP-binding cassette transporters G5/G8 (ABCG5/G8) in the intestine.
Effects of Saponin from Trigonella Foenum-Graecum Seeds on Dyslipidemia
Tall, "ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins," Proceedings of the National Academy of Sciences of the United States of America, vol.
ATP synthase [beta]-chain overexpression in SR-BI knockout mice increases HDL uptake and reduces plasma HDL level
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.
Overcoming resistance in breast cancer
For instance, ATP-binding cassette transporters encoded by genes known as ABCB1 and ABCC1 are involved in eliminating carcinogens from the lungs, protecting them against inhaled toxins.
Gene variants behind cigarette smoke metabolism linked to lung cancer risk
ATP-binding cassette transporters in macrophages: promising drug targets for treatment of cardiovascular disease.
Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues
The roles of ATP-binding cassette transporters, such as ABCC1, ABCC11, and ABCG2, in breast cancer patients have been reported.
Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer
Kou et al., "[alpha]-Lipoic acid ameliorates foam cell formation via liver X receptor a-dependent upregulation of ATP-binding cassette transporters A1 and G1," Free Radical Biology and Medicine, vol.
Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-[alpha]-induced inflammation in macrophages: role of liver X receptor [alpha]
Welch et al., "Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes," Journal of Biological Chemistry, vol.
Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries
Klucken et al., "The gene encoding ATP-binding cassette transporter I is mutated in Tangier disease," Nature Genetics, vol.
ApoA-I/HDL generation and intracellular cholesterol transport through cytosolic lipid-protein particles in astrocytes

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