atosiban


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atosiban

A competitive OXYTOCIN receptor antagonist used to quieten a uterus contracting at an undesirably early stage of gestation and allow greater maturation of the fetus before birth. A brand name is Tractocile.
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In the PROLONG trial, OBE022 or matching placebo is administered daily for 7 days to pregnant women who are receiving an infusion of atosiban for 48 hours, the current standard of care therapy for preterm labor in the countries in which the PROLONG trial is being conducted.
Recent studies have shown that oxytocin receptor inhibitors (atosiban) may also be effective.
[32] described a case of maternal atrial fibrillation after sequential use of nifedipine and atosiban for the treatment of preterm labor.
Paciente de 45 anos, sextigesta, con embarazo de alto riesgo por insuficiencia renal cronica materna, que ingresa en hospital regional, procedente de hospital comarcal, por amenaza de parto prematuro en semana 27+2, con tratamiento tocolitico (Atosiban) en tercer paso (8 ml/h).
These tocolytic agents include atosiban, magnesium sulphate, betamimetics, calcium channel blockers, nitric oxide donors.
SAN DIEGO -- Nifedipine and atosiban for tocolysis in women with threatened preterm delivery had similar rates of adverse perinatal outcomes in a randomized clinical trial, but an increase in perinatal mortality in those treated with nifedipine is raising concerns about its safety.
Atosiban has lower maternal complications and a higher price as compared to [beta]2 agonists.
The probability of delivery being delayed by 48 hours was greatest with prostaglandin inhibitors (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.14-12.34), followed by magnesium sulfate (OR, 2.76; 95% CI, 1.58-4.94), calcium channel blockers (OR, 2.71; 95% CI, 1.17-5.91), beta mimetics (OR, 2.41; 95% CI, 1.27-4.55), and the oxytocin receptor blocker atosiban (OR, 2.02; 95% CI, 1.10-3.80), compared with placebo.