Dahchour et al., "Unravelling the bacterial vaginosis-associated biofilm: a multiplex Gardnerella Vaginalis and Atopobium vaginae
fluorescence in situ hybridization assay using peptide nucleic acid probes," PLOS ONE, vol.
We observed that women who had spontaneous abortion showed significant increases (P < 0.05) in Atopobium vaginae, Megasphaera spp., Gardnerella vaginalis, Leptotrichia amnionii, and Sneathia sanguinegens compared to nonabortion group (Table 2).
Baumstarck et al., "Screen-and-treat program by point-of-care of Atopobium vaginae and Gardnerella vaginalis in preventing preterm birth (AuTop trial): study protocol for a randomized controlled trial," Trials, vol.
Kuijper, "First report of atopobium vaginae bacteremia with fetal loss after chorionic villus sampling," Journal of Clinical Microbiology, vol.
vaginalis and Atopobium vaginae
, thus making it possible to identify pregnant women with BV and in this way provide therapy and prevent the risk of premature birth.
Gardnerella vaginalis, Atopobium vaginae
, and Prevotella and Lactobacillus species made up 81% of the isolates.
(12) Another study showed that the molecular quantification of Atopobium vaginae (DNA level, [10.sup.8] copies/mL) and G vaginalis (DNA level, [10.sup.9] copies/mL) had the highest predictive value for BV, with excellent sensitivity (95%), specificity (99%), and positive (95%) and negative (99%) predictive values, whereas G vaginalis concentration alone of <105 org/mL had less than 35% positive predictive value.
Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis.
Association of Atopobium vaginae
, a recently described metronidazole resistant anaerobe, with bacterial vaginosis.
(5-8) The essential participants in pathological polymicrobial associations, which could be used as markers for BV, are Gardnerella vaginalis (that grows under appropriate microaerophilic conditions) and anaerobic Atopobium vaginae. (3-8) Other microorganisms involved in BV microbiota are very diverse and include anaerobes, such as Peptostreptococcus spp., Mobiluncus spp., Prevotella spp., Bacteroides spp., Fusobacterium spp., and facultative anaerobes.
The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy.
Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae