domain

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do·main

(dō-mān'),
1. Homologous unit of approximately 110-120 amino acids, groups of which make up the light and heavy chains of the immunoglobulin molecule; each serves a specific function. The light chain has two domains, one in the variable region and one in the constant region of the chain; the heavy chain has four to five domains, depending on the class of immunoglobulin, one in the variable region and the remaining ones in the constant region.
2. A region of a protein having some distinctive physical feature or role.
3. An independently folded, globular structure composed of one section of a polypeptide chain. A domain may interact with another domain; it may be associated with a particular function. Domains can vary in size.
[Fr. domaine, fr. L. dominium, property, dominion]
Farlex Partner Medical Dictionary © Farlex 2012

domain

(dō-mān′)
n.
Biology Any of three primary divisions of organisms, consisting of the eukaryotes, bacteria, and archaea, that rank above a kingdom in taxonomic systems based on similarities of DNA sequences.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

domain

EBM
Any of a collection of observations with a topic-specific commonality about each subject in a clinical trial, which the Clinical Data Interchange Standards Consortium (CDISC) divides into different classes:
• Interventions class;
• Events class;
• Findings class.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

do·main

(dō-mān')
1. Homologous unit of 110-120 amino acids, groups of which make up the light and heavy chains of the immunoglobulin molecule; each serves a specific function. The light chain has two domains, one in the variable region and one in the constant region of the chain; the heavy chain has four to five domains, depending on the class of immunoglobulin, one in the variable region and the remaining ones in the constant region.
2. A region of a protein having some distinctive physical feature or role.
3. An independently folded, globular structure composed of one section of a polypeptide chain. A domain may interact with another domain; it may be associated with a particular function. Domains can vary in size.
[Fr. domaine, fr. L. dominium, property, dominion]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

domain

1. Of a protein, a discrete length of the amino acid sequence that is known to be associated with a specific function.
2. Of a chromosome, a region in which supercoiling occurs independently of other domains; or a region that includes a gene of raised sensitivity to degradation by DNASE I.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

domain

  1. a structurally or functionally distinct part of a PROTEIN.
  2. any of three primary groupings (‘superkingdoms’): ARCHAEA, BACTERIA or EUCARYA, into which all ORGANISMS are placed in modern CLASSIFICATIONS based on genetic structures and sequences.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Patient discussion about domain

Q. What other illnesses are similar to asthma? I am 45 years old. My doctor suspects I might have adult asthma but there has yet been a final diagnosis made. What other problems might this be?

A. Before diagnosing someone as asthmatic, alternative possibilities should be considered. A clinician taking a history should check whether the patient is using any known bronchoconstrictors (substances that cause narrowing of the airways, e.g., certain anti-inflammatory agents or beta-blockers). Chronic obstructive pulmonary disease, which closely resembles asthma, is correlated with more exposure to cigarette smoke, an older patient, and decreased likelihood of family history of atopy. Your physician should examine these possibilities as well before diagnosing.

More discussions about domain
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