ATLANTIS

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ATLANTIS

Alteplase ThromboLysis for Acute Noninterventional Therapy in ischaemic Stroke. A trial testing the efficacy of rt-PA (alteplase) in patients with acute ischaemic stroke when administered between three and five hours after the onset of symptoms. Alteplase had been previously approved for use within three hours of symptoms onset.
 
Primary endpoint
Excellent neurologic recovery at day 90.
 
Conclusion
No rt-PA benefit on 90-day end point in patients treated between three and five hours, but risk of symptomatic ICH increased with rt-PA; rt-PA for stroke should be limited to three hours post-symptom onset.
References in periodicals archive ?
In Bacon's New Atlantis, which I would suggest might be taken as paradigmatic in this respect, the New Atlantians know the rest of the world without being themselves known.
Sixteen-year-old Noam Alvaro survives a deadly magic virus that kills his undocumented father and destroys most of his immigrant Atlantian community.
The Atlantian Chronicles is a story of survival, mystery, betrayal, and of two mismatched lovers whose accidental encounter becomes a means for humankind's survival.