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Related to Ativan: Zyprexa


trademark for preparations of lorazepam, an antianxiety agent, sedative, and anticonvulsant.


Apo-Lorazepam (CA), Ativan, Dom-Lorazepam (CA), Novo-Lorazem (CA), Nu-Loraz (CA), PHL-Lorazepam (CA), PMS-Lorazepam (CA), Pro-Lorazepam (CA)

Pharmacologic class: Benzodiazepine

Therapeutic class: Anxiolytic

Controlled substance schedule IV

Pregnancy risk category D


Unknown. Thought to depress CNS at limbic system and disrupt neurotransmission in reticular activating system.


Injection: 2 mg/ml, 4 mg/ml

Solution (concentrated): 2 mg/ml

Tablets: 0.5 mg, 1 mg, 2 mg

Indications and dosages


Adults: 2 to 3 mg P.O. daily in two or three divided doses. Maximum dosage is 10 mg daily.


Adults: 2 to 4 mg P.O. at bedtime

Premedication before surgery (as antianxiety agent, sedative-hypnotic, or amnestic)

Adults: 0.05 mg/kg (not to exceed 4 mg) deep I.M. injection at least 2 hours before surgery, or 0.044 mg/kg (not to exceed 2 mg) I.V. 15 to 20 minutes before surgery. For greater amnestic effect, give up to 0.05 mg/kg (not to exceed 4 mg) I.V. 15 to 20 minutes before surgery.

Status epilepticus

Adults: 4 mg I.V. given slowly (no faster than 2 mg/minute). If seizures continue or recur after 10 to 15 minutes, repeat dose. If seizure control isn't established after second dose, other measures should be used. Don't exceed 8 mg in 12 hours.

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Acute alcohol withdrawal syndrome


• Hypersensitivity to drug, other benzodiazepines, polyethylene or propylene glycol, or benzyl alcohol
• Acute angle-closure glaucoma
• Coma or CNS depression
• Hepatic or renal failure


Use cautiously in:
• hepatic or renal impairment
• history of suicide attempt, drug abuse, depressive disorder, or psychosis
• elderly patients
• pregnant or breastfeeding patients.


• For I.V. use, dilute with equal volume of compatible diluent, such as normal saline solution or dextrose 5% in water. Keep resuscitation equipment and oxygen at hand.

Give each 2 mg of I.V. dose slowly, over 2 to 5 minutes. Don't exceed rate of 2 mg/minute.
• Don't give parenteral form to children younger than age 18.

Adverse reactions

CNS: amnesia, agitation, ataxia, depression, disorientation, dizziness, drowsiness, headache, incoordination, asthenia

CV (with too rapid I.V. administration): hypotension, bradycardia, tachycardia, apnea, cardiac arrest, cardiovascular collapse

EENT: blurred vision, diplopia, nystagmus

GI: nausea, abdominal discomfort

Other: increased or decreased appetite


Drug-drug.CNS depressants (including antidepressants, antihistamines, benzodiazepines, sedative-hypnotics): additive CNS depression

Hormonal contraceptives: increased lorazepam clearance

Drug-herbs.Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Smoking: increased metabolism and decreased efficacy of lorazepam

Patient monitoring

During I.V. administration, monitor ECG and cardiovascular and respiratory status.
• Monitor vital signs closely.
• Evaluate for amnesia.
• Watch closely for CNS depression. Institute safety precautions as needed to prevent injury.

Monitor for signs and symptoms of overdose (such as confusion, hypotension, coma, and labored breathing).
• Assess liver function tests and CBC.

Patient teaching

• Tell patient and family about drug's possible CNS effects. Recommend appropriate safety precautions.
• Explain that with long-term use, drug must be discontinued slowly (typically over 8 to 12 weeks).
• Instruct patient to avoid alcohol, because it increases drowsiness and other CNS effects.
• Caution patient to avoid smoking, because it speeds drug breakdown in body.
• Advise female patient to inform prescriber if she is pregnant or breastfeeding.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.


A trademark for the drug lorazepam.


a trademark for a benzodiazepine antianxiety agent (lorazepam).


Lorazepam, see there.


A brand name for LORAZEPAM.
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by willfully causing and permitting Ruben Navarro [the patient] to be placed in a situation in which his health was endangered by the prescription of excessive amounts of morphine and Ativan, and/or by the introduction of Betadine into his stomach.
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In 1981 I was put on Ativan which was like a valium and I was on that until 1986.
The survey asked each plan for information about restrictions on five drugs: Advair, an asthma medication; Norvasc, a blood-pressure medication; Aciphex, a heartburn medication; Lexapro, an anti-depressant and anti-anxiety medication; and Ativan, another anti-anxiety medication.
I was also on Ativan for anxiety, prescribed before my hysterectomy.
Anti-anxiety agents such as buspirone (Buspar) and benzodiazapines (Valium, Klonapin, Ativan and Xanax, for example) have been studied little in autism.
The death of the South Korean prompted the Philippine police to focus on the so-called Ativan gang notorious for its method of drugging victims before robbing them of jewelry and cash.
The painkillers (Vicodin, Percodan, and Percocet) and tranquillisers (Xanax, Ativan and Valium) have replaced cocaine and heroin as the trendy drugs.