It has been shown that manipulating expression of P4H[alpha]1 affects atherosclerotic plaque
stabilization, while different manipulations of P4H[alpha]1 have different influences on lesional collagen synthesis [11-13].
Tissue samples were obtained from atherectomy of coronary artery or carotid atherosclerotic plaques
by surgeon during CABG.
The mechanism underlying acute coronary syndrome (ACS) involves rupture of atherosclerotic plaques
, platelet aggregation, and thrombosis (5,6).
noticed that vessel wall and plaque microvessels are increased in ruptured atherosclerotic plaques
, suggesting a contributory role for neovascularization of vasa vasorum in the process of plaque rupture.
Badimon, "Controlling the angiogenic switch in developing atherosclerotic plaques
: possible targets for therapeutic intervention," Vascular Cell, vol.
Schoneveld et al., "Athero-express: differential atherosclerotic plaque
expression of mRNA and protein in relation to cardiovascular events and patient characteristics.
microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque
Pathology and vulnerability of atherosclerotic plaque
: identification, treatment options, and individual patient differences for prevention of stroke.
Subsequently, a possible pathogenetic mechanism was identified, as this particular cell population is capable of infiltrating and destabilizing atherosclerotic plaques
The text and figures that follow will review new developments in our understanding of the pathogenesis of atherosclerosis and newways that changes in atherosclerotic plaque
size and volume can be measured.
[Lp-PLA.sub.2] is highly upregulated in atherosclerotic plaque
; and through hydrolysis of oxidized LDL, this enzyme generates two pro-inflammatory mediators, lysophosphatidylcholine and non-esterified oxidized fatty acid.
Using a 17-segment model of the coronary arteries to assess for the presence of calcific or noncalcific plaque, the investigators calculated a total plaque score by summing the number of coronary segments with visible atherosclerotic plaque
. They calculated the FRS using age, sex, total cholesterol level, HDL cholesterol level, smoking history, and blood pressure.