Recently, Cicalese et al [33] compared pattern of cell division between CSC and normal stem cells; and showed that both symmetrical and
asymmetrical cell divisions occurred in CSC while
asymmetrical cell division was associated only with normal stem cells;
asymmetrical cell division would result in production of progenitor cells while symmetrical cell division would give rise to two daughter cells which may be responsible for populating the tumour [33].
Rac, one of the Rho GTPases expressed in mouse oocytes (Natale and Watson, 2002; Kumakiri et al., 2003), controls spindle stability and anchoring to the cortex and thus the
asymmetrical cell division; however, it is not involved in spindle migration during mouse oocyte maturation (Halet and Carroll, 2007).
The second book in this two-volume series on Wnt signaling molecules describes vertebrate and invertebrate models of study such as
asymmetrical cell division in C.