Recently, Cicalese et al  compared pattern of cell division between CSC and normal stem cells; and showed that both symmetrical and asymmetrical cell divisions
occurred in CSC while asymmetrical cell division
was associated only with normal stem cells; asymmetrical cell division
would result in production of progenitor cells while symmetrical cell division would give rise to two daughter cells which may be responsible for populating the tumour .
Rac, one of the Rho GTPases expressed in mouse oocytes (Natale and Watson, 2002; Kumakiri et al., 2003), controls spindle stability and anchoring to the cortex and thus the asymmetrical cell division
; however, it is not involved in spindle migration during mouse oocyte maturation (Halet and Carroll, 2007).
The second book in this two-volume series on Wnt signaling molecules describes vertebrate and invertebrate models of study such as asymmetrical cell division