MitoQ given to mice for five months stopped the development of Alzheimer's-like pathologies such as cognitive decline, oxidative stress, A[beta] accumulation, astrogliosis
, synaptic loss, and caspase activation in the brain.
The co-occurrence of glioma with other neuropathologies that feature astrogliosis
leads to the question of whether reactive glial conditions may lead to neoplastic transformation.
Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis
and inflammatory response in a mouse model of cortical stab injury.
Furthermore, astrocytes respond to all forms of CNS insults such as infection, trauma, stroke, epilepsy, brain tumors, multiple sclerosis and neurodegenerative diseases through a process commonly referred to as reactive astrogliosis
(RA), which is a reliable and sensitive pathological marker of CNS structural lesions (Sofroniew and Vinters, 2010; Burda and Sofroniew, 2014).
sup] A study on SOD1 (G93A) mutant mice showed that early disease was associated with astrogliosis
while late disease was correlated with microglial activation.
Histologically, several processes drive the formation of MS plaques: inflammation, myelin breakdown, astrogliosis
, oligodendrocyte injury, neurodegeneration and remyelination (1,2).
STAT3 is a critical regulator of astrogliosis
and scar formation after spinal cord injury.
In accordance with this view, a significant astrogliosis
was observed eight days after the end of CAI.
as a therapeutic target for neurodegenerative diseases.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis
and microgliosis, leading to neuronal dysfunction and loss in the brain.
Histopatologia Datos de encefalitis con predominio de linfocitos T con celulas microgliales activadas (tipicamente formando nodulos, pero no necesario) y astrogliosis
Las enfermedades prionicas se caracterizan por presentar en el encefalo de los individuos afectados vacuolizaciones con apariencia microscopica de esponja, astrogliosis
y depositos proteicos de [PrP.