It results from the fact that ALS is a slowly progressing neurodegenerative disease characterized, first of all, by motor neuron loss and astrogliosis
with ongoing consumption and downregulation of S100B in the course of disease.
Integrative analysis of global gene expression 2 identifies opposite patterns of reactive astrogliosis
in 3 aged human prefrontal cortex 4.
A semiquantitative analysis of reactive astrogliosis
demonstrates its correlation with the number of intact motor neurons after transient spinal cord ischemia.
GFAP immunoreactivity reveals neocortical tissue in the initial stages of GFAP deposition, indicating early repair response. Reactive astrogliosis
has been established as one of the key components of the cellular response to brain injury. Our data as well as that of others reveal GFAP positive expression at boundaries between brain parenchyma and fluids, which may indicate specific areas of damage from blast exposure, which is consistent with the general principles of blast biophysics. We identified different trends of glial activation between the frontal lobe and hippocampus.
In CJD cases, lesions that were observed as hyperintense on T2-weighted images in basal ganglia were described and these signals were associated with astrogliosis
Atrophy, neuronal losses and astrogliosis
can be seen in the brain tissue underlying the leptomeningeal angiomas, which may lead to structural impairments in the cortex.
LaPlaca, "Strain rate-dependent induction of reactive astrogliosis
and cell death in three-dimensional neuronal-astrocytic co-cultures,", Brain Res, vol.
As a result, the myelin sheath destruction and astrogliosis
formation occurs in both white and gray matters which can interfere with correct transmission of nerve impulse and lead to neuronal dysfunction.
The study published in Cell Reports found that the LZK gene of astrocytes can be turned on to prompt a recovery response called astrogliosis
, in which these star-shaped cells proliferate around injured neurons and form a scar.
It is not clear if more pronounced astrogliosis
leads to poorer neuronal integration, or whether both events occur secondary to greater tissue trauma.
Hamill et al., "Activation of protease-activated receptor-1 triggers astrogliosis
after brain injury," The Journal of Neuroscience, vol.
AD is a progressive neurodegenerative disease characterized by neuroinflammation with reactive microglia, astrogliosis
, proinflammatory cytokines, amyloid-[beta] (A[beta]) peptide deposition, and progressive memory loss .