Panels show multifocal mild to severe perivascular and neuropil infiltration of lymphocytes and monocytes (blue arrows in A-C); meningitis in a sulcus (black arrow in A); glial cell activation with notable astrocytosis
, neuron degeneration, and neuronophagia (arrowhead in B); occasional hemorrhage (blue arrow in D); mild periventricular spongiosis (blue arrows in C); and meningitis (black arrow in C).
On histologic examination, all 3 doves had moderate to severe meningoencephalitis characterized by large numbers of plasma cells, lymphocytes, and macrophages with gliosis and astrocytosis
In the sentence that begins, astrocytosis
, please provide the percentage, where indicated.
The findings suggest that the disease may begin with an unknown insult that stimulates reactive astrocytosis
--in familial forms of Alzheimer's at least--and that the cells themselves could be a legitimate therapeutic target, wrote the investigators, led by Dr.
Publication: 'Diverging longitudinal changes in astrocytosis
and amyloid PET in autosomal-dominant Alzheimer's disease', Elena Rodriguez-Vieitez, Laure Saint-Aubert, Stephen F.
Diffuse axonal damage, myelin impairment, astrocytosis
and inflammatory response following microinjections of NMDA into the rat striatum," Inflammation, vol.
Numerous other conditions, among which oxidative stress (17) and inflammation, due to microglia activation and astrocytosis
, may concur to produce the structural and functional alterations typically found in AD brain (18).
Pathologically, ALS is characterized by extensive loss of lower motor neurons in the spinal cord and brain stem, atrophy of ventral roots, degeneration of upper motor neurons in the motor cortex and corticospinal tract, somatic and axonal inclusions of aberrant neurofilament proteins, and reactive astrocytosis
Cortical tubers are considered hamartomatous lesions which are differentiated with abnormal glial, neuronal cells and astrocytosis
The increased or "reactivated" astrocytes, in a process called astrocytosis
, play a role in secondary injury following neurotrauma , and astrocytosis
could be an early sign of chronic traumatic encephalopathy .
Continuance of chorea despite normalization of blood glucose in some patients and the fact that abnormal movements are generally observed on the one side of the body are contradictory to a metabolic pathology, while the fact that chorea may be observed bilaterally and observation of only neuron loss, gliosis and reactive astrocytosis
, but not infarction or hemorrhagia are contradictory to vascular pathology (9,10).
Neuropathological features of TME include spongiform degeneration in the neuropil of the brain, astrocytosis
and the formation of PrP deposits of the TME agent.