Nutrient patterns and asthenozoospermia
: a case-control study.
Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia
. Hum Reprod 2008;23:1957-62.
Poor sperm motility is also called asthenozoospermia
The case report of Kordus et al (11) shows that even in severe cases of asthenozoospermia
, ICSI (12) can overcome the inability of the spermatozoa to reach the ovum and produce healthy offspring.
Huang et al., "Increased N6methyladenosine in human sperm RNA as a risk factor for asthenozoospermia
," Scientific Reports, vol.
Huang et al., "Sperm motility inversely correlates with seminal leptin levels in idiopathic asthenozoospermia
," International Journal of Clinical and Experimental Medicine, vol.
showed that the expression of mitochondrial protein nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Fe-S protein 3 (NDUFS3) was significantly decreased in the sperm of patients with Asthenozoospermia
(AS), and DJ-1 may play a role in maintaining mitochondrial function by means of the association with NDUFS3 during spermatogenesis in the testes.
Significant positive correlations were found among PHB expression, mitochondrial membrane potential, and sperm motility in normozoospermia, asthenozoospermia
, and oligoasthenozoospermia samples (6).
Thus, a possible pathogenic role in infertile men when asthenozoospermia
is the main critical problem may be cured; however, this should be proven scientifically.
(14) found a significantly lower catalase activity in patients with asthenozoospermia
, asthenoteratozoospermia, and oligoasthenoteratozoospermia than in normozoospermic males.
OncBioMune Pharmaceuticals, Inc (OncBioMune or the Company), a revenue-stage biopharmaceutical company engaged in the development of targeted cancer therapies and a proprietary vaccine technology and commercialization of a portfolio of products internationally, is pleased to report that the Companys licensed male fertility product Andfrt demonstrated a clinically meaningful benefit in treating asthenozoospermia
, a medical condition defined by abnormal sperm motility.
It is known that asthenozoospermia
(poor/dysfunctional sperm motility) is the commonest disorder in male infertility, yet there is no drug that men can currently take for it to improve the chances of conception.