astemizole


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astemizole

Histamal® Therapeutics A non-sedating H1-receptor antagonist-antihistamine used for seasonal rhinitis–hay fever, hives Adverse effects Minimal sedation, anticholinergic effects

astemizole

An ANTIHISTAMINE drug used in the treatment of hay fever and allergic skin disorders. A brand name is Hismanal.
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Benzimidazole is also a privileged scaffold of many drugs such as omeprazole, rabeprazole, lansoprazole, dexlansoprazole, pantoprazole, esomeprazole (proton pump inhibitors), mebendazole (antihelmentic), albendazole (antimicrobial), and astemizole (antihistaminic) [26-28],
Maccioni, "Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease," Journal of Alzheimer's Disease, vol.
Henceforth, this preclinical study was undertaken to compare the sedative property of fexofenadine, a newer the second-generation antihistaminic with terfenadine, astemizole, and cetirizine in albino rats using potentiation of phenobarbitone sleep time model.
The overall efficacy rate of the treatment was 81.0% (17/21), which is higher than 60.0% (6/10) of Astemizole and 67.0% (8/12) of Tefenadine [29] and comparable to the most optimum results of acupuncture treatment [30].
Astemizole, a nonspecific inhibitor of Kv 10.1 and Kv11.1 potassium channels, significantly decreased cell proliferation and increased apoptosis in vitro in the liver cancer cell lines HepG2 and HuH7 [167].
Danazol [11], decursin [14], hydroxyebastine [24], thelephoric acid [21], telmisartan [17], TSAHC [11] inhibited CYP2J2-mediated astemizole O-demethylation activity with [IC.sub.50] values of 0.02, 6.95, 1.50, 3.23, 0.42, and 2.60 [micro]M, respectively.
In vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least 100 times more potent than paroxetine as an inhibitor of the metabolism of several substrates for CYP3A4, including astemizole, triazolam, and cyclosporine.
Benzimidazole is an interesting heterocyclic ring system because it is present in naturally occurring cyanocobalamin and several known commercialized drugs such as mebendazole, astemizole, and emedastine difumarate.
The two compounds are already marketed as the drugs tacrolimus and astemizole.