23andMe has published numerous genome-wide association studies
, but this is the first 23andMe study to include association results across a broad set of phenotypes (i.
1) To perform genome wide association studies
to identify regions associated with relevant health traits;
Our genomewide association studies
showed that specific variants near the GDF15 gene on chromosome 19p13.
The researchers explored the genetics of late-onset Alzheimer's disease by performing a three-stage analysis of data accrued in several genome-wide association studies
involving more than 35,000 subjects (JAMA 2010;303:1832-40).
No single gene within the RAAS appears to predominate in the association studies
and there appears to be an increasing complexity and sophistication in association studies
This "enviromics" approach, which mirrors genome-wide association studies
, harnesses high-speed computers and publicly accessible databases.
The research, published online in Nature, drew on previous genome-wide association studies
that linked a non-coding stretch of chromosome 9p21 with coronary artery disease (CAD) and showed that people who carry certain single nucleotide mutations in this stretch of DNA have an increased chance of developing the disease.
In the past two years alone, genome-wide association studies
have found about 100 new genetic variants linked to 40 common diseases, including type II diabetes, prostate cancer and heart disease.
The consortium (funded by the NHLBI, NIEHS, NCI, NHGRI, and NIGMS) brings together expertise in genetics, epidemiology, biostatistics, and bioinformatics to develop and test innovative, informative, and cost-effective study designs and analytical strategies for performing genome-wide association studies
on complex diseases.
The private-public Genetic Association Information Network (GAIN) will accelerate genome association studies
Tokyo, Japan, July 22, 2005 - (JCNN) - RIKEN and Perlegen Sciences Japan jointly announced on July 21 that the two parties have entered into a collaborative agreement to conduct high-resolution, whole genome association studies
with the aim of collaborating to search genetic origins of various diseases.
Researchers searching for functions of genes are increasingly employing association studies
of unrelated affected patients and controls, instead of the more traditional linkage studies concentrating on hereditary diseases in families.