Previous genome wide
association studies have identified association of large number of loci with risk of CHD in different populations.
Under the study, researchers performed a meta-analysis of seven whole-genome
association studies including more than 10,000 women with PCOS and 100,000 controls of European ancestry.
A role in genetics has also been established from twin studies, family history studies and, more recently, genome-wide
association studies. Our understanding about whether adhering to a healthy lifestyle could attenuate the effect of genetic background on risk of incident stroke is currently unknown.
For the first time, we proved that NIPT data can be used in genome-wide
association studies to understand the genetic architecture of complex traits and disease, said Siyang Liu, senior research scientist in BGI and first author of the study.
In the study, researchers looked at height and BMI differences in 9, 416 people from 14 European countries and used data from genome-wide
association studies.
10, 2018 (HealthDay News) -- Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified, according to a meta-analysis of genome-wide
association studies (GWAS) published online Aug.
With the advent of genome sequencing and genotyping platforms, genome-wide
association studies (GWAS) have become a powerful tool and increasingly used to dissect the genetics of quantitative trait loci (QTL) in several domestic livestock species.
The impact of genome-wide
association studies and genetic-association studies has become enormous in the past ten years, providing researchers with extensive data repositories [1].
But, as genome-wide
association studies continue to reveal, most conditions are more complex, arising from dozens or hundreds of genetic mutations working together to cause disease.
The single-nucleotide polymorphisms (SNPs) in the CUB and Sushi multiple domains-1 (CSMD1) gene were recently identified in genome-wide
association studies (GWAS) as significant genetic markers for schizophrenia (SZ) and cognitive performance.
In a general setting, the effect of phenotypic misclassification on statistical power of genetic
association studies has been previously explored [11-14].
Genetic
Association Studies: Background, Conduct, Analysis, Interpretation
