Previous genome wide association studies
have identified association of large number of loci with risk of CHD in different populations.
Under the study, researchers performed a meta-analysis of seven whole-genome association studies
including more than 10,000 women with PCOS and 100,000 controls of European ancestry.
A role in genetics has also been established from twin studies, family history studies and, more recently, genome-wide association studies
. Our understanding about whether adhering to a healthy lifestyle could attenuate the effect of genetic background on risk of incident stroke is currently unknown.
For the first time, we proved that NIPT data can be used in genome-wide association studies
to understand the genetic architecture of complex traits and disease, said Siyang Liu, senior research scientist in BGI and first author of the study.
In the study, researchers looked at height and BMI differences in 9, 416 people from 14 European countries and used data from genome-wide association studies
10, 2018 (HealthDay News) -- Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified, according to a meta-analysis of genome-wide association studies
(GWAS) published online Aug.
With the advent of genome sequencing and genotyping platforms, genome-wide association studies
(GWAS) have become a powerful tool and increasingly used to dissect the genetics of quantitative trait loci (QTL) in several domestic livestock species.
The impact of genome-wide association studies
and genetic-association studies has become enormous in the past ten years, providing researchers with extensive data repositories .
But, as genome-wide association studies
continue to reveal, most conditions are more complex, arising from dozens or hundreds of genetic mutations working together to cause disease.
The single-nucleotide polymorphisms (SNPs) in the CUB and Sushi multiple domains-1 (CSMD1) gene were recently identified in genome-wide association studies
(GWAS) as significant genetic markers for schizophrenia (SZ) and cognitive performance.
In a general setting, the effect of phenotypic misclassification on statistical power of genetic association studies
has been previously explored [11-14].
Genetic Association Studies
: Background, Conduct, Analysis, Interpretation