Aspergillus fumigatus


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As·per·gil·lus fu·mi·ga·tus

a fungal species that yields the antibiotics fumigacin and fumigatin; common cause of aspergillosis in humans and birds.

Aspergillus fumigatus

The fungal species that is the most common cause of human aspergillosis, which may enter via the lungs or less commonly skin, and which may invade blood vessels and disseminate to various organs. Aspergillus spp branch at 45º angle.
 
Vectors
Soil and organic debris, bird droppings.
 
Clinical findings
See table below.

Diagnosis
Complement fixation, immunodiffusion.
 
DiffDx
Pseudallescheria spp, fusariosis.

Pulmonary aspergillosis
• Allergic bronchopulmonary aspergillosis—Hypersensitivity reaction to the fungus and most common in asthmatics.
• Saprophytic aspergillosis (Aspergilloma)—Most common form; noninvasive; colonisation of pre-existing cavities.
• Chronic necrotising aspergillosis—Airway-invasive aspergillosis; semi-invasive aspergillosis; chronic cavitary pneumonic disease (often affects patients with preexisting chronic lung disease).
• Angioinvasive aspergillosis—Affects immunocompromised patients and is often fatal.

Aspergillus fumigatus

Microbiology The fungal species that is the most common cause of human aspergillosis, which may infect the lungs, invade blood vessels, or disseminate to various organs. See Aspergillosis.

As·per·gil·lus fu·mi·ga·tus

(as'pĕr-jil'ŭs fyūm'i-gā'tŭs)
Widely spread in the environment, a fungal species found in the soil or decaying vegetation; most common cause of aspergillosis in humans, particularly in the immunocompromised patient. Associated with pulmonary, bone, ocular, nasal, and deep organ disease; extremely angioinvasive.
References in periodicals archive ?
Krikstaponis, A., A., Lugauskas, T.E., Krysinska, Z., Prazmo, and J., Dutkiewicz, (2001) Enzymatic activities of Aspergillus fumigatus strains isolated from the air at waste landfills.
High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis.
herbarum 11 (8) Acacia 10 (7.3) Orach 10 (7.3) Birch 7(5.1) Oak white 6 (4.38) Aspergillus fumigatus 6 (4.38) Plantain 4 (3) Total 137(100) % of repetition 137/55=(249) HDMs: House dust mites, INH: Inhalant allergen, BDG: Bermuda grass, C.
Biochemical and molecular characterization of alkalothermophilic proteases purified from Aspergillus fumigatus. J Biol Chem Res.
Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient.
Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles?
The most widely reported species were Aspergillus fumigatus, Aspergillus flavus, and Candida albicans.
Cytokine and chemokine responses following pulmonary challenge with Aspergillus fumigatus: obligatory role of TNF-alpha and GM-CSF in neutrophil recruitment.
also confirmed the role of IL-1 in controlling aspergillus fumigatus infection in the murine lung and speculated the important role of IL-1 in pulmonary fungal infection [24].
Cultures obtained from tissue in the operating room were positive for Aspergillus fumigatus and negative for bacteria and viruses.
Septate filamentous fungi with acute angle branching characteristic of Aspergillus fumigatus were noted on retinochoroidal biopsy (Figure 4(a)).