ASPA

(redirected from Aspartoacylase)
Also found in: Acronyms, Wikipedia.

ASPA

A gene on chromosome 17p13.3 that encodes aspartoacylase, which catalyses the conversion of N-acetyl_L-aspartic acid–NAA to aspartate and acetate. NAA hydrolysis by aspartoacylase may help maintain white matter. 
Molecular pathology Defects in ASPA cause Canavan disease
References in periodicals archive ?
Homozygosity for mutation G212A of the gene for aspartoacylase is associated with atypical form of Canavan's disease.
Canavan Disease Synonyms: ASPA Deficiency, Aspartoacylase Deficiency.
Aspartoacylase deficiency: the enzyme defect in Canavan disease.
(143.) Reuben Matalon et al., Aspartoacylase Deficiency and
(145.) Aspartoacylase is the enzyme responsible for breaking down
In 1988, his group found excessively large amounts of NAA in the brains of Canavan's patients and identified aspartoacylase deficiency as the possible cause of the disease.