ASPA

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ASPA

A gene on chromosome 17p13.3 that encodes aspartoacylase, which catalyses the conversion of N-acetyl_L-aspartic acid–NAA to aspartate and acetate. NAA hydrolysis by aspartoacylase may help maintain white matter. 
Molecular pathology Defects in ASPA cause Canavan disease
References in periodicals archive ?
Canavan disease is a leukodystrophy attributable to a deficiency of aspartoacylase (EC 3.
The mutation plants a misfit amino acid into the gene product, an enzyme called aspartoacylase.
In 1988, his group found excessively large amounts of NAA in the brains of Canavan's patients and identified aspartoacylase deficiency as the possible cause of the disease.