aspartate transaminase

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aspartate transaminase

 (AST) (ASAT) [ah-spahr´tāt trans-am´ĭ-nās]
an enzyme that catalyzes the reversible transfer of an amino group from aspartate to α-ketoglutarate to form glutamate and oxaloacetate, requiring the coenzyme pyridoxal phosphate; it is normally present in serum and in various body tissues, especially in the heart and liver. (See accompanying table.) It is released into the serum as the result of tissue injury, especially injury to the heart or liver, hence the concentration in the serum may be increased in myocardial infarction or acute damage to hepatic cells. Serum levels are also increased in some muscle diseases, such as progressive muscular dystrophy. Called also glutamic-oxaloacetic transaminase.

as·par·tate a·mi·no·trans·fer·ase (AST),

an enzyme catalyzing the reversible transfer of an amine group from l-glutamate to oxaloacetate, forming α-ketoglutarate and l-aspartate; an aid in diagnosing viral hepatitis and myocardial infarction.

Patient discussion about aspartate transaminase

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References in periodicals archive ?
In the biochemical tests, aspartate amino transferase (AST) (278 IU/L) and alanine aminotransferase (ALT) (148 IU/L) were found to be increased, whereas serum electrolytes, bilirubin, alkaline phosphatase, total protein, albumin, gamma glutamyl transpeptidase and renal function tests were found to be normal.
Alanine amino transferase (ALT) and aspartate amino transferase (AST) were quantified in kinetic mode, while following the guidelines of the Institute for Reference Materials and Measurements (IFCC), in serum by means of commercial kits ALT / GPT Liquiform and AST / GOT Liquiform (Labtest, Minas Gerais, Brazil).
T1 T2 T3 T4 SEM * ALT 14.78 14.82 14.72 14.84 0.49 AST 168.37 170.63 168.69 171.93 3.82 ALP 421.12 416.68 427.08 427.67 9.86 GGT (1) 4.38 4.33 4.42 4.43 0.03 Alanine Amino Transferase (ALT), Aspartate Amino Transferase (AST), Alkaline Phosphatase (ALP), Gamma-Glutamyl-Transferase (GGT); Values in the same row not sharing a common superscript are significantly different (p < 0.05); T1) without CM, T2) replacing 30% of SBM with CM (contained 10% CM), T3) replacing 60% of SBM with CM (contained 20% CM), T4) replacing 90% of SBM with CM (contained 30% CM).
total protein, albumin, total cholesterol, Aspartate amino transferase (AST) and Alanine amino transferase (ALT), calcium and phosphorus were estimated in serum using diagnostic kit and semiautomatic analyzer.
Similarly, a significant decrease (p<0.05, p<0.01 and p<0.001) in the hepatic enzyme markers, alkaline phosphatase (ALP) alanine amino transferase (ALT) and aspartate amino transferase (AST), in treated rats with both moringa leaf and seed extracts were observed at doses; 100, 200 and 400 mg/kg by Olayemi et al.
Plasma total proteins (g/dL), creatinine (mg/dL), blood urea nitrogen (mg/dL), plasma glucose (mg/dL), triglycerides (mg/dL), albumin (g/dL), alanine amino transferase (ALT; IU/L), and aspartate amino transferase (AST; IU/L) activities were analyzed using available kits supplied by Bio Merieux SA, F-69280 Marcy l'Etoile, France.
In this study, the rates of cirrhosis were calculated from National Health and Nutrition Examination Survey (NHANES) data by using two surrogate indicators, the aspartate amino transferase to platelet ratio index (APRI) and the FIB-4 score.
Liver function tests were totally deranged with total bilirubin level being 9.6 mg% (direct bilirubin was 7.70 mg% and indirect bilirubin was 1.9 mg%), alanine amino transferase being 52 IU/L, aspartate amino transferase being 1045 IU/L, and alkaline phosphatase being 203 IU/L.
laboratory findings were a leukocyte count of 14 200/mm 3, with 91% neutrophils, a hemoglobin level of 11.7g/dl, a platelet count 71000/[mm.sup.3], a glucose level of 110mg/dl, a blood urea nitrogen level of 24mg/dl, a creatinine level of 1.9mg/dl, an alanine amino transferase level of 250 U/l, an aspartate amino transferase level of 46 U/l, a total bilirubin level of 1.2mg/dl.
Biochemical analysis in the serum of TAA-treated rats revealed a significant increase in the levels of tumor necrosis factor (TNF-a) and transforming growth factor (TGF-AY), as well as, the activities of aspartate amino transferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT).
His initial laboratory values were as follows; haemoglobin: 10.7g/dl (normal: 14-18) white blood cells 3200/mm3 (normal:5000-11000) platelet:130.000/mm3 (normal: 130000-450000) prothrombin time 16.8 minutes aspartate amino transferase (AST): 126 U/L (normal: 0-35) alanine amino transferase (ALT): 102 U/L (normal:0-45) albumin: 2.6 g/dl (normal: 3.5-5.2) globulin: 3.4g/dl (normal: 2.3-3.5) alpha- fetoprotein (AFP): 61 ng/ml (normal: 0-13) His hepatitis B surface antigen and delta hepatitis antibody were also positive.
The serum separated was used for assay of Alanine amino transferase (ALT), Aspartate amino transferase (AST), alkaline phosphatase (ALP), albumin, triglycerides and serum bilirubin according to the instructions provided by the company.