asparagine ligase

(redirected from Asparagine synthetase)
Also found in: Wikipedia.

as·par·a·gine li·gase

an acid:ammonia ligase (amide synthetase) forming l-asparagine and l-glutamate from l-aspartate and l-glutamine, with the concomitant cleavage of ATP to AMP and pyrophosphate. Under nonphysiological conditions, the mammalian enzyme can use ammonia as the nitrogen donor. Asparagine ligase also displays a glutaminase-like activity.
References in periodicals archive ?
the team discovered that the appearance of asparagine synthetase -- the enzyme cells used to make asparagine -- in a primary tumour was strongly associated with later cancer spread.
Asparagine synthetase (ASNS) is an expression status present in various tumour types, such as leukaemia, lymphoma and pancreatic cancer.
These ESTs were highly homologous with expansion, b-xyloglucan endotransglycosylase, acyl-CoA-binding protein, asparagine synthetase, seed storage protein, lignin-related peroxidase, cytochrome P450, polyubiquitin, translation initiation factor, and nutrient storage protein.
The team identified the gene affected by the mutation code for asparagine synthetase, the enzyme responsible for synthesising the amino acid asparagine.
Washington, Dec 2 ( ANI ): The deficiency of asparagine synthetase, which is found in meat, eggs and dairy products, caused by rare genetic disorder affects development of the brain.
Genes for enzymes that are also upregulated include a glutathione S-transferase, an S-adenosyl methionine synthase, [beta]-glucosidase, [beta]-galactosidase, cysteine proteases, glutamine synthetase, asparagine synthetase, aspartic proteases, nucleases, monodehydroascorbate reductase and phosphate transporter PhPT1 (Meyer et al.
1994), and asparagine synthetase (pBLT 95)(GenBank Acc.
An example of the type of information the researchers are trawling for is provided by a drug called L-asparaginase and a gene called asparagine synthetase (AS).
We've identified a candidate biomarker, asparagine synthetase (ASNS) that may predict L-ASP activity against solid tumors.
ISLAMABAD -- The deficiency of asparagine synthetase, which is found in meat, eggs and dairy products, caused by rare genetic disorder affects development of the brain.
This study evaluated the utility of Oncaspar in solid tumors and lymphomas as well as assessed the correlation of Oncaspar activity with cellular levels of asparagine synthetase (ASNS).
Certain malignant cells, including many pancreatic and ovarian cell lines, lack asparagine synthetase and therefore may depend on exogenous L-asparagine to survive.
Full browser ?