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A glycoprotein without a sialic acid moiety; such proteins are recognized by asialoglycoprotein receptors and are targeted for degradation.
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This receptor, a C-type lectin, is involved in the recognition and binding of terminal galactose on the glycan chains and is responsible for the clearance of asialoglycoproteins, and redetermined as an Ashwell-Morell Receptor (126).
The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins. J Biol Chem 1974; 249(17): 5536-43.
Sia covers penultimate galactose residue that is recognized by an asialoglycoprotein receptor.
At the same time, a hepatic galactose specific receptor (asialoglycoprotein receptor) from a rabbit liver was characterized (120) and a similar clearance mechanism for the desialylated cells, for erythrocytes in the rabbit was reported for the first time (121,122).
Mammalian hepatocytes possess large numbers of high-affinity, cell-surface receptors (asialoglycoprotein receptor, ASGP-R) that can bind asialoglycoproteins [13-15].
Smyk et al., "Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found," Autoimmunity Reviews, vol.
Weigel, "Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes," The Journal of Biological Chemistry, vol.
A membrane receptor protein for asialoglycoproteins. Methods Enzymol 1974;34:688-91.
A 3D model for the human hepatic asialoglycoprotein receptor (ASGP-R).
a3-Galactosylated glycoproteins can bind to the hepatic asialoglycoprotein receptor.
Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.
For example, competition for clearance by the asialoglycoprotein receptor of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).

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