A first biomarker study sponsored by Inventiva showed that, despite ERT treatment, the current standard of care, leukoGAG levels remained very high and were not impacted when measured one hour after ERT infusion although the activity of the
arylsulfatase B[sup.2] enzyme was very high.
MLD is a neurodegenerative disease caused by lysosomal
arylsulfatase enzyme deficiency due to ARSA gene mutations.
The soil samples collected on day 25 and 50 of the experiment were tested for activity of five enzymes:
arylsulfatase, dehydrogenases, catalase, urease, acid phosphatase, and alkaline phosphatase.
Compartmentalization and regulation of
arylsulfatase activities in Streptomyces sp., Microbacterium sp.
Five smes will develop products that include
arylsulfatase b (for human enzyme replacement therapy), A vaccine for infectious spleen and kidney necrosis virus in fish, Two highly potent hiv neutralising antibody-based fusion proteins and plant chimaeric virus-like-particles for a diagnostic kit.
(12) The organism has positive reactions for two-week
arylsulfatase test, pyrazinamidase, growth on T2H, 10-day tween hydrolysis test, and urease.
The laboratory findings of patients with ML III involve the abundance of some lysosomal enzymes in plasma including
arylsulfatase. Genetic transmission is autosomal recessive and consanguinity was observed in all of our patients with ML III.
Arylsulfatase activity, which is partly responsible for S cycling in soils [20], was chosen as a representative S-acquiring enzyme and was determined with p-nitrophenyl sulfate as the substrate in an acetate buffer at pH 5.8 [20].
Metachromatic leukodystrophy (MLD) is a genetic disorder caused by the deficiency of the enzyme
arylsulfatase A (ARSA) in lipid metabolism [1-3].
Very low
arylsulfatase A and cerebroside sulfatase activities in leukocytes of healthy members of metachromatic leukodystrophy family.
Rinderknecht, "Plasma
arylsulfatase and [beta]-glucuronidase in acute alcoholism," Clinica Chimica Acta, vol.
HAH_1665, annotated as a polysaccharide biosynthesis protein, and HAH_1666, annotated as an
arylsulfatase A family protein, might all together participate in the synthesis of the acidic EPS (Figure S1A available online at https://doi.org/10.1155/2017/5842958).
