Ah receptor

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Ah receptor

A receptor that is detectable in many tissues and organs which binds various environmental pollutants, including polycyclic aromatic hydrocarbons, hetercyclic amines and polychlorinated aromatic compounds (e.g., dioxins, dibenzofurans and biphenyls), and mediates the well-known carcinogenic effects of these agents. Once bound via a helix-loop-helix motif and activated, the Ah receptor-ligand complex is transported to the nucleus where it binds to specific DNA sequences and variously turns genes on or off.
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References in periodicals archive ?
The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway.
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.
A biological entity that tightly links genes and the environment is a nuclear receptor best known for its role in xenobiotic metabolism: the aryl hydrocarbon receptor (AHR).
GH: growth hormone; IGF-1: insulin-like growth factor-I; ULNR: upper limit of the normal age- and sex-matched range; GNAS: guanine nucleotide-binding protein, alpha stimulating; AIP: aryl hydrocarbon receptor interacting protein; PTTG: pituitary tumor transforming gene; RQ: relative quantification; NA: not applicable.
Karhu, "Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene," Endocrine Reviews, vol.
Duarte, "The aryl hydrocarbon receptor: multitasking in the immune system," Annual Review of Immunology, vol.
When ICZ binds to and activates the Aryl hydrocarbon receptor (AHR) in the intestinal lining, it aids in maintaining a healthy balance in the gut flora and immune surveillance, and enhances host barrier function, according to the researchers.
From the biochemical point of view, the aryl hydrocarbon receptor (AHR) is a highly conserved, developmentally regulated, and ligand-activated member of the bHLH/PAS family of transcription factors.
ADX: Adrenodoxin ADR: Adrenodoxin reductase AHR: Aryl hydrocarbon receptor BNF: [beta]-naphthoflavone BaP: Benzo[a]pyrene CcO: Cytochrome c oxidase CYP: cytochrome P450 NPOR: NADPH-cytochrome P450 oxidoreductase DCFDA: 2',7'-dichlorofluorescin diacetate mtDNA: Mitochondrial DNA OCR: Oxygen consumption rate ROS: Reactive oxygen species.
The aryl hydrocarbon receptor (AHR) pathway has been widely studied and it appears to be the main protein receptor that influences CYP1A1 induction.
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