artificial chromosome

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Related to Artificial chromosomes: Yeast artificial chromosome, expression vector

artificial chromosome

n.
A large sequence of DNA, such as a human artificial chromosome or a bacterial artificial chromosome, that is constructed in a laboratory to function like a chromosome or inserted into a cell to be replicated and expressed. Artificial chromosomes have been used in gene mapping and in modeling genetic diseases.

artificial chromosome

The result of a biotechnology still at an experimental stage. Human chromosomes, consisting of a centromere of highly repetitive DNA sequences, telomeric DNA, a marker gene and some random sequences of genomic DNA, have been successfully prepared. When these ingredients were introduced into a human cell line they became coated with histone proteins and formed highly coiled structures. They also replicated and passed on copies to daughter cells through more than 200 cell divisions.
References in periodicals archive ?
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
Kouprina said that conventional gene therapy uses vectors like viruses to insert genes into chromosomes, which can cause problems which do not happen with human artificial chromosomes because they do not interfere with other parts of the genome.
The construction of bacterial artificial chromosome (BAC) libraries, p.
* Chromos Molecular Systems, founded in 1996 and located in British Columbia, is developing what could be the most powerful genetic engineering technology to date: artificial chromosomes, which would enable the engineering of multiple, complex human traits.
The program for the evening was entitled 'Artificial Chromosomes and Plant Toxins as Therapeutic Agents'.
The task of creating such herds may be made much easier by the artificial chromosomes developed by Chromos Molecular Systems, near Vancouver, BC.
SCIENTISTS at the Medical Research Council in Edinburgh have developed artificial chromosomes to help combat the defective genes which cause illnesses such as cystic fibrosis and haemophilia.
A DNA contig of this region spanning 2,400 kb was constructed from large-capacity yeast artificial chromosomes and P1 bacteriophage clones (76).
The technique, developed by a team at the University of California, San Diego, uses bacterial artificial chromosomes (BACs) to insert defective copies of genes into stem cells.
Laboratory techniques and applications for researchers investigating the identification and function of genes relevant to normal physiology and cancer are described by specialists in specific aspects of gene identification and full-length gene cloning, gene profiling, the chromatin modification of gene regulation, bacterial artificial chromosomes, cancer cytogenetic analysis, and other topics.
Comparative sequence analysis of colinear barley and rice bacterial artificial chromosomes. Plant Physiol.
Metaphase and interphase fluorescence in situ hybridization mapping of the rice genome with bacterial artificial chromosomes. Proc.