artificial chromosome

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Related to Artificial chromosomes: Yeast artificial chromosome, expression vector

artificial chromosome

n.
A large sequence of DNA, such as a human artificial chromosome or a bacterial artificial chromosome, that is constructed in a laboratory to function like a chromosome or inserted into a cell to be replicated and expressed. Artificial chromosomes have been used in gene mapping and in modeling genetic diseases.

artificial chromosome

The result of a biotechnology still at an experimental stage. Human chromosomes, consisting of a centromere of highly repetitive DNA sequences, telomeric DNA, a marker gene and some random sequences of genomic DNA, have been successfully prepared. When these ingredients were introduced into a human cell line they became coated with histone proteins and formed highly coiled structures. They also replicated and passed on copies to daughter cells through more than 200 cell divisions.
References in periodicals archive ?
A new generation of human artificial chromosomes for functional genomics and gene therapy.
Kouprina said that conventional gene therapy uses vectors like viruses to insert genes into chromosomes, which can cause problems which do not happen with human artificial chromosomes because they do not interfere with other parts of the genome.
The construction of bacterial artificial chromosome (BAC) libraries, p.
A DNA contig of this region spanning 2,400 kb was constructed from large-capacity yeast artificial chromosomes and P1 bacteriophage clones (76).
The method was originally developed to improve upon older copy number assays that use long genomic fragments such as bacterial artificial chromosomes.
The technique, developed by a team at the University of California, San Diego, uses bacterial artificial chromosomes (BACs) to insert defective copies of genes into stem cells.
Laboratory techniques and applications for researchers investigating the identification and function of genes relevant to normal physiology and cancer are described by specialists in specific aspects of gene identification and full-length gene cloning, gene profiling, the chromatin modification of gene regulation, bacterial artificial chromosomes, cancer cytogenetic analysis, and other topics.
Comparative sequence analysis of colinear barley and rice bacterial artificial chromosomes.
Metaphase and interphase fluorescence in situ hybridization mapping of the rice genome with bacterial artificial chromosomes.
Further in the future, parents will be able to add genes that improve their progeny's immune systems, mental acuity, and athletic abilities by installing artificial chromosomes.
In 1996 Resnick, with NIEHS colleagues Vladimir Larionov and Natalya Kouprina, perfected a method using yeast artificial chromosomes, or YACs, for the specific isolation of entire human genes.

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