artemisinin

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ar·te·mis·i·nin

(ar'te-mis'in-in),
A sesquiterpene antimalarial and antischistosomal drug derived from Artemisia annua; a. is a potent and rapidly acting blood schizontocide used in the treatment of malaria; active against chloroquine-resistant Plasmodium falciparum and chloroquine-sensitive P. falciparum and P. vivax.

artemisinin

(är′tə-mĭs′ĭ-nĭn)
n.
1. A compound, C15H22O5, that is obtained from a species of artemisia (Artemisia annua) and has antimalarial activity.
2. Any of several semisynthetic derivatives of this compound that are used to treat malaria, usually in combination with other drugs.

artemisinin

An antimalarial drug derived from Artemisia annua . The drug is claimed to be effective in treating cerebral malaria and is active against chloroquine-resistant P. falciparum and chloroquine-sensitive P. falciparum and P. vivax . The drug is a traditional Chinese remedy. See also QUINGHAO.
References in periodicals archive ?
Artemisinin (also known as qinghao su) and its derivatives are a new class of antimalarials derived from the sweet wormwood plant Artemisia annua.
Despite clinical activity of artemisinins against cancer, longitudinal studies on the efficacy of artemisinin and Artemisia annua preparations upon longer application times are missing.
The nonsense falcipain 2a mutation, which is present in F32-ART3, might contribute to reducing sensitivity of F32-ART5 to artemisinins and some quinolines (other than chloroquine), but it is unlikely for pyrimethamine, whose activity is not related to hemoglobin metabolism.
A number of molecular studies have been carried out in different countries for detection of point mutation in PfATPase6 gene that was believed to be the main target of artemisinins.
Major finding: Parasite clearance half-life was markedly slow (5 hours or longer), indicating resistance to artemisinins, across sites in Southeast Asia, but not in India or Africa.
A synthetic version of the world's most effective antimalarial drug, artemisinin, can now be made in just 3 weeks rather than 18 months.
There is an urgent need for coordinated action against this public health threat, as called for in the Global Plan for Artemisinin Resistance Containment.
Currently, the most widely used medical treatment for malaria comes from the plant-based compound artemisinin, which has been successful in decreasing malaria infections worldwide -- the World Health Organization (WHO) (http://www.
Artemisinins have been reported to be relatively safe, however there are concerns on some recently reported adverse effects.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin combination therapy (ACT) for chloroquine resistant malaria [7].
in order to allow for early detection of artemisinin resistance.
Artemisinins are a class of compounds that include artesunate, artemether, and artemisinin and have potent antimalarial activity.