artemisinin

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ar·te·mis·i·nin

(ar'te-mis'in-in),
A sesquiterpene antimalarial and antischistosomal drug derived from Artemisia annua; a. is a potent and rapidly acting blood schizontocide used in the treatment of malaria; active against chloroquine-resistant Plasmodium falciparum and chloroquine-sensitive P. falciparum and P. vivax.
Farlex Partner Medical Dictionary © Farlex 2012

artemisinin

(är′tə-mĭs′ĭ-nĭn)
n.
1. A compound, C15H22O5, that is obtained from a species of artemisia (Artemisia annua) and has antimalarial activity.
2. Any of several semisynthetic derivatives of this compound that are used to treat malaria, usually in combination with other drugs.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

artemisinin

An antimalarial drug derived from Artemisia annua . The drug is claimed to be effective in treating cerebral malaria and is active against chloroquine-resistant P. falciparum and chloroquine-sensitive P. falciparum and P. vivax . The drug is a traditional Chinese remedy. See also QUINGHAO.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Currently, the most widely used medical treatment for malaria comes from the plant-based compound artemisinin, which has been successful in decreasing malaria infections worldwide -- the World Health Organization (WHO) (http://www.who.int/mediacentre/factsheets/fs094/en/index.html) reports that malaria mortality rates around the world have fallen by over 25 percent since 2000.
Structure-Activity-Relationship (SAR) of artemisinins on some biological systems in male guinea pigs.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin combination therapy (ACT) for chloroquine resistant malaria [7].
in order to allow for early detection of artemisinin resistance.
In a review of 108 trials of artemisinins involving 9,241 patients, only 0.9% had isolated elevated aspartate aminotransferase associated with artemisinin derivatives (3,5).
The alert follows a study which found that treatments derived from artemisinin, the basis of the most effective anti-malaria drugs, took twice as long to clear malaria parasites from Cambodian patients as it did in neighbouring Thailand.
In this way, the profiles of methylene blue and artemisinins, which quickly and effectively eliminate the parasites in the red blood cells, complement each other," says Professor Dr.
Unlike the case for chloroquine and most other antimalarials, "there's probably no resistance to the artemisinins in Africa," Rosenthal says.
Some international health agencies, pressured by well-meaning activists, are pushing Mozambique to change its entire malaria infrastructure and buy artemisinins now--but won't provide the money to make the drugs affordable, he says.
The role of holotransferrin and ferric iron in the form of iron (II)-glycine sulfate (Ferrosanol[R]) for the enhancement of tumor-inhibiting effects of artemisinins is well documented (Efferth et al.
Several investigations underlined the possible immunomodulatory effects of artemisinin and its derivatives, such as a Treg proliferation by Foxp3 up-regulation and suppression of Th17 pathway that can diminish immune reactivity and tissue inflammation (7).