melarsoprol

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melarsoprol

 [mel-ahr´so-prol]
an antiprotozoal agent effective against trypanosomes.

melarsoprol

An older arsenical used to treat trypanosomiasis caused by Trypanosoma cruzi (Chagas disease) and T brucei gambiense (which causes 95% of cases of sleeping sickness).

Adverse effects
Arsenic poisoning, convulsions, loss of consciousness, rash, fever, nausea, vomiting, bloody stool; treatment-related fatalities are not uncommon. Pentamidine is the drug of choice for first-stage T brucei gambiense infection. Other agents (suramin, eflornithine and nifurtimox) are available in the US from the Centers for Disease Control and Prevention (CDC).

melarsoprol

A combination of melarsan oxide and dimercaprol used to treat TRYPANOSOMIASIS. The drug is highly effective but must be used with caution because of sometimes dangerous side effects including the JARISCH-HERXHEIMER REACTION. The drug is on the WHO official list.

melarsoprol

an antiprotozoal effective against Trypanosoma spp.