arsenical

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arsenical

 [ahr-sen´ĭ-k'l]
1. pertaining to arsenic.
2. a compound containing arsenic; arsenicals were once widely used in medicine, but have now mostly been replaced by antibiotics. However, some are still used to treat infectious diseases, especially those caused by protozoa, as well as skin disorders and blood dyscrasias; they must be administered with caution because of their toxicity. All arsenicals are toxic to humans and some are carcinogenic. See also arsenic poisoning.

ar·sen·i·cal

(ar-sen'i-kăl),
1. A drug or agent, the effect of which depends on its arsenic content.
2. Denoting or containing arsenic.

arsenical

(är-sĕn′ĭ-kəl)
adj.
Of or containing arsenic.
n.
A drug or preparation containing arsenic.

ar·sen·i·cal

(ahr-sen'i-kăl)
1. Denoting or containing arsenic.
2. A drug or agent, the effect of which depends on its arsenic content.
3. A class of chemical agents that contain arsenic.

arsenical

1. pertaining to arsenic.
2. a compound containing arsenic.

arsenical herbicide
includes monosodium or disodium methanearsonates. See also organic arsenical (below).
organic arsenical
includes aliphatic organic arsenicals, e.g. the pharmaceuticals cacodylic and phenarsonic acids, the herbicides monosodium and disodium methanearsonates, aromatic organic arsenicals, e.g. trivalent phenylorganic arsenicals like thiacetarsamide, arsphencomplexamine, and pentavalent phenylorganic arsenicals like arsanilic acid, roxarsone, nitarsone. Poisoning by organic arsenicals causes blindness and incoordination or restlessness, convulsions, incoordination, screaming. Recovery is spontaneous if the toxin is discontinued but some piglets may remain blind.
arsenical pyrites
an arsenic-rich ore.
arsenical sheepdip, cattledip
usually contains arsenic and sulfur with 20% soluble arsenic and 3% insoluble arsenious sulfide.
arsenical smoke
factory smoke effluent from processes using arsenic-rich ores may pollute local pasture with arsenic trioxide.
arsenical weedkiller
contains sodium or potassium arsenite or thioarsenites. They may contain up to 40% arsenic trioxide.
References in periodicals archive ?
Together, these observations indicate that methylated arsenicals are proatherogenic and can cause changes in plaque components in a manner similar to that of NaAs[O.
Se ha propuesto varias explicaciones al cancer arsenical en el humano, pero no existe aun un modelo definido que exprese el porque esta asociacion; parece ser que cada tejido tuviese su propia vulnerabilidad.
Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols.
RESIDENTIAL USE OF PRESSURE-TREATED WOOD (adapted from University of Maryland Agricultural Engineering Facts 164) inorganic arsenicals penta creosote Vegetable and produce storage yes no no Greenhouse framing and shelves yes yes* yes* Wood in contact with plants yes no no Patios, decks, walkways yes yes yes (clean and free of surface residues) Poles and timbers (framing) yes yes* yes* Outdoor furniture and chairs yes yes* yes* (frequent or prolonged contact with bare skin) Cutting boards, countertops no no no Food storage containers no no no Residential buildings: (sawdust & debris must be removed) interior use yes no no components in ground contact yes yes* no laminated beams yes yes* no log cabins/homes yes no no
Next, utilizing an in vitro extraction procedure that simulates the human gastrointestinal tract, we estimated the bio-accessible iAs in rice and provided an upper-bound assessment available through a quantitative (complete speciation of all arsenicals in a solid rice sample) As speciation-based analysis using ion chromatography inductively coupled plasma-mass spectrometry (ICICP-MS).
In this way, only those arsenicals giving volatile arsines were detected.
Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations.
A just published preclinical article, "Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line", by Boise et al in Molecular Cancer Therapeutics May 2009, further elucidates the mechanism of action of darinaparsin and highlights substantial differences between darinaparsin and inorganic arsenic trioxide, aspects of darinaparsin likely to be included in the discussion session following the abstract presentation, "Mechanisms of Action of Arsenicals in Hematologic Malignancies".
From 10,451 participants in the NHANES 2003-2010 urine arsenic subsamples, we excluded 387 missing total urine arsenic, arsenobetaine, or DMA; 229 who were pregnant; 880 who were missing BMI, cotinine, urinary creatinine, or education information; and 5,626 with detectable arsenobetaine because seafood arsenicals markedly contribute to total arsenic exposure and DMA and make it difficult to evaluate the contribution of other foods to iAs exposure (NavasAcien et al.
Patent and Trademark Office for patent applications numbered 11/252,966 and 11/349,043, covering claims for various organic arsenic compounds, including purified crystalline darinaparsin (ZIO-101), glycolic arsenicals, and the oral pharmaceutical composition of an organic arsenic compound, and their use in the treatment of cancer.
From 1999, the European Union ceased the use of arsenicals as feed additives (European Commission 1999).
Patent and Trademark Office for patent applications numbered 11/252,966 and 11/349,043, covering claims for various organic arsenic compounds, including purified crystalline darinaparsin, glycolic arsenicals, and the oral pharmaceutical composition of an organic arsenic compound, and their use in the treatment of cancer.