De Prezet al., "Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats," Journal of the American Society of Nephrology, vol.
Aristolochic acid nephropathy (AAN) is one of the best-known iatrogenic kidney diseases caused by Aristolochia herbal medications .
At present time a lot of derivatives of aristolochic acids
have been found and their structures also reported (Michl et al., 2014; Kumar et al., 2003).
With the outcome of their study, the researchers hope to raise awareness of the risks of aristolochic acids
and reduce the global disease burden from this severe condition.
* Aristolochic acid
, a botanical contaminant in some herbal products.
On May 31, 2000, the Food and Drug Administration issued a letter to health care professionals concerning the nephrotoxicity and carcinogenicity of botanical products containing aristolochic acid
. During this time, the FDA also issued a letter to representatives of the dietary supplement trade associations, urging them to review their manufacturing procedures and ensure botanical products are free of aristolochic acid
In the present work, we determined better conditions to extract and detect aristolochic acids
from lower biomass samples.
Quantitative analysis of aristolochic acids
, toxic compounds, contained in some medicinal plants.
Misuse, misidentification and adulteration of the products containing aristolochic acids
(AAs) might have been the cause (CFSAN/US FDA, 2001).
The preparation has attracted widespread attention, since it caused aristolochic acid
nephropathy (AAN) [2, 3].
The scientists reviewed worldwide cases of aristolochic acid
nephropathy (N) - a type of kidney failure caused by the intake of these acids.