Arimidex


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Related to Arimidex: tamoxifen

anastrozole

Arimidex

Pharmacologic class: Nonsteroidal aromatase inhibitor

Therapeutic class: Antineoplastic

Pregnancy risk category D

Action

Reduces serum estradiol levels with no significant effect on adrenocorticoid or aldosterone level; decreases stimulating effect of estrogen on tumor growth

Availability

Tablets: 1 mg

Indications and dosages

Postmenopausal women with hormone receptor-unknown or hormone receptor-positive advanced breast cancer or with advanced breast cancer after tamoxifen therapy; adjuvant treatment for hormone receptor-positive breast cancer

Adults: 1 mg P.O. daily

Contraindications

• Hypersensitivity to drug or its components

• Women of childbearing age

Precautions

Use cautiously in:

• ischemic heart disease

• breastfeeding patients

• children (safety and efficacy not established).

Administration

• Verify that patient isn't pregnant before giving drug.

Adverse reactions

CNS: headache, weakness, dizziness, depression, paresthesia, lethargy

CV: chest pain, peripheral edema, vasodilation, hypertension, thromboembolic disease

EENT: pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia, dry mouth

GU: vaginal bleeding, leukorrhea, vaginal dryness, pelvic pain

Musculoskeletal: decreased bone mineral density, fractures, bone or back pain, muscle weakness

Respiratory: dyspnea, cough

Skin: rash

Other: food distaste, weight gain, swelling, hot flashes, flulike symptoms, tumor flare hypersensitivity reactions (including anaphylaxis, angioedema, urticaria)

Interactions

Drug-diagnostic tests. Hepatic enzymes, low-density lipoproteins, total cholesterol: increased levels

Patient monitoring

Monitor patient closely for hypersensitivity reactions.

• Check regularly for signs and symptoms of thromboembolic disease, especially dyspnea and chest pain.

• Monitor for circulatory overload (suggested by peripheral edema, cough, and dyspnea).

• Assess for signs and symptoms of depression. Evaluate patient for suicidal ideation.

• Monitor liver function test results.

Patient teaching

Instruct patient to immediately notify prescriber if signs and symptoms of hypersensitivity occur (such as itching or swelling of face, lips, or throat).

Advise patient to immediately report signs and symptoms of thromboembolic disease and circulatory overload.

• Emphasize importance of preventing pregnancy during therapy.

• Tell patient to contact prescriber if she develops signs or symptoms of depression.

• Caution patient to avoid driving and other hazardous activities until she knows how drug affects concentration and alertness.

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Inform patient that she'll undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

anastrozole

An aromatase inhibitor, which converts androstenedione to estradiol in peripheral fat.
 
Indications
Postmenopausal women with advanced oestrogen-dependent breast cancer that does not respond to tamoxifen; unlike tamoxifen, anastrozole is not associated with increased risk of endometrial cancer.

Arimidex®

Anastrozole Oncology A nonsteroidal 3rd-generation selective aromatase inhibitor used to manage postmenopausal ♀ whose advanced breast CA is resistant to tamoxifen. See Breast cancer.

Arimidex

A brand name for ANASTROZOLE.
References in periodicals archive ?
Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer.
AstraZeneca plans to continue to market and supply ATACAND, ATACAND HCT, ARIMIDEX and CASODEX outside of the US.
ANI Pharmaceuticals Inc (Nasdaq: ANIP), an integrated specialty pharmaceutical company developing, manufacturing, and marketing branded and generic prescription pharmaceuticals, has acquired the NDAs and United States rights to market ATACAND, ATACAND HCT, ARIMIDEX, and CASODEX from AstraZeneca, an Anglo-Swedish multinational pharmaceutical and biopharmaceutical company.
Astra's so-called "patent cliff" - when revenues drop off as patents expire - is particularly steep as breast cancer drug Arimidex has already lost patent protection, while acid reflux treatment Nexium and biggest seller Crestor will lose patent protection in the next four years.
Featured Article: Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer.
Breckenridge also launched anastrozole (Arimidex), bicalutamide (Casodex), granisetron (Kytril), hydrocortisone enema (Cortenema), letrozole (Femara), neomycin tablets and terbinafine (Lamisil) in the last year and recently received approval for levetiracetam tablets, which it plans to launch soon.
Aromasin, AstraZeneca's Arimidex, and Femara from Novartis, are in a family of medicines known as aromatase inhibitors that work by halting production of estrogen, a hormone that fuels cancer growth.
- Anastrozole remained superior to tamoxifen as an adjuvant treatment for invasive breast cancer in postmenopausal women, based on 10-year follow-up data from the Arimidex, Tamoxifen Alone or in Combination trial known as ATAC.
"I had 57 radiation treatments, then I opted to take Arimidex, rather than being put on chemo.
In the next paragraph, you can read about the side effects seen with Arimidex which include: "hot flashes, joint symptoms, weakness, mood changes, pain, sore throat, nausea and vomiting, depression, high blood pressure, osteoporosis (!) swelling of arms/ legs, and headache.
Breast cancer treatment utilizes anti-estrogen hormones such as tamoxifen (Nolvadex) and anastrozole (Arimidex); 80 percent of women being treated suffer side effects.