argininosuccinic acid

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argininosuccinic acid

 [ahr″-jĭ-ne´no-suk-sin″ik]
a compound normally formed in urea formation in the liver, but not normally present in urine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ar·gi·ni·no·suc·cin·ic ac·id

(ar'ji-ni-nō-sŭk-sin'ik as'id),
Compound formed as an intermediate in the conversion of l-citrulline to l-arginine in the urea cycle.
Farlex Partner Medical Dictionary © Farlex 2012

ar·gi·ni·no·suc·cin·ic ac·id

(ahr'ji-ni-nō-sŭk-sin'ik as'id)
Formed as an intermediate in the conversion of l-citrulline to l-arginine in the urea cycle.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
ASA is a rare genetic urea cycle disorder characterised by deficiency or lack of the enzyme argininosuccinate lyase (ASL), which is central to two metabolic pathways: the liver-based urea cycle, which detoxifies ammonia and the citrulline-nitric oxide cycle, which synthesises nitric oxide from L-arginine.
Glutamine stimulates argininosuccinate synthetase gene expression through O-glycosylation of Sp1 in Caco-2 cells.
Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene.
Bruno et al., "Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency," Stem Cell Research & Therapy, vol.
Wildemann, "Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with [beta]-amyloid 1-42 in vitro," Neuroscience Letters, vol.
Tumor necrosis factor-reduces argininosuccinate symthase expression and nitric oxide production in aorticendothelial cells.
Carbamoyl phosphate reacts with ornithine to produce citrulline, which is transported out of mitochondria and then reacts with aspartate to form argininosuccinate. Argininosuccinate is converted by argininosuccinase into fumarate and arginine.
The ASS1 gene provides instructions for making argininosuccinate synthase 1, which is responsible for the third step of the urea cycle.
Cit is transported out from mitochondrion and bound to aspartate by argininosuccinate synthase, and aspartate is provided by the mitochondrial transporter citrin.
Eichler, "Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells," The American Journal of Physiology--Heart and Circulatory Physiology, vol.
Spot 12 contained a mixture of four proteins: argininosuccinate synthase (nine peptides), elongation factor 1-alpha (two peptides), alanine aminotransferase2 (two peptides), and 26S protease regulatory subunit6B homolog (five peptides, also found in other spots) (Table 1, peptide data not shown).